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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $40 | In Stock | |
50 mg | $56 | In Stock | |
100 mg | $81 | In Stock | |
500 mg | $198 | In Stock | |
1 g | $293 | In Stock | |
1 mL x 10 mM (in DMSO) | $29 | In Stock |
Description | AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with inhibitory concentration 50 (IC50) values of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It achieves its PRMTs inhibitory activity by obstructing peptide-substrate binding [1]. |
In vitro | In S180 cells and U2OS cells, AMI-1, free acid (0.6 mM, 1.2 mM, 2.4 mM; 48 hours, 72 hours, 96 hours) inhibits cell viability[3]. |
In vivo | AMI-1, free acid (0.5 mg; administered daily via subcutaneous injection for 7 days) reduces tumor weight in male Kunming mice with S180 cell xenografts[3]. |
Molecular Weight | 504.49 |
Formula | C21H16N2O9S2 |
Cas No. | 134-47-4 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (118.93 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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