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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

Ammonium Glycyrrhizinate

🥰Excellent
Catalog No. T6384Cas No. 1407-03-0
Alias Glycyram, Glycamil, AMGZ

Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.

Ammonium Glycyrrhizinate
Other Forms of Ammonium Glycyrrhizinate:
Ammonium glycyrrhizinateT289153956-04-0
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Ammonium Glycyrrhizinate

🥰Excellent
Purity: 98.41%
Catalog No. T6384Alias Glycyram, Glycamil, AMGZCas No. 1407-03-0
Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
Pack SizePriceAvailabilityQuantity
100 mg27 €In Stock
1 mL x 10 mM (in DMSO)43 €In Stock
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Purity:98.41%
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COA HPLC HNMR LCMS
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Product Introduction

Bioactivity
Description
Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
In vitro
Ammonium glycyrrhizinate (AG) markedly protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also dose-dependently inhibits FeSO(4)-induced reactive oxygen radicals.
In vivo
Ammonium glycyrrhizinate down-regulates the TNF-α level and up-regulates IL-10 level and inhibits the cAMP-PDE activity in the lung tissue of mice. Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate increases HDL levels in rats. Ammonium glycyrrhizinate significantly decreases cholesterol, triglyceride, LDL and very VLDL levels in rats.
AliasGlycyram, Glycamil, AMGZ
Chemical Properties
Molecular Weight839.96
FormulaC42H62O16·NH3
Cas No.1407-03-0
SmilesN.C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](O[C@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)C(O)=O)C(O)=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 155 mg/mL (184.5 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 5 mg/mL (5.95 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.1905 mL5.9527 mL11.9053 mL59.5266 mL
5 mM0.2381 mL1.1905 mL2.3811 mL11.9053 mL
DMSO
1mg5mg10mg50mg
10 mM0.1191 mL0.5953 mL1.1905 mL5.9527 mL
20 mM0.0595 mL0.2976 mL0.5953 mL2.9763 mL
50 mM0.0238 mL0.1191 mL0.2381 mL1.1905 mL
100 mM0.0119 mL0.0595 mL0.1191 mL0.5953 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Ammonium Glycyrrhizinate53956-04-011-beta-hydroxysteroid dehydrogenase
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