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Product Introduction

Bioactivity

Description	Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
In vitro	Ammonium glycyrrhizinate (AG) markedly protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also dose-dependently inhibits FeSO(4)-induced reactive oxygen radicals.
In vivo	Ammonium glycyrrhizinate down-regulates the TNF-α level and up-regulates IL-10 level and inhibits the cAMP-PDE activity in the lung tissue of mice. Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate increases HDL levels in rats. Ammonium glycyrrhizinate significantly decreases cholesterol, triglyceride, LDL and very VLDL levels in rats.
Alias	Glycyram, Glycamil, AMGZ

Chemical Properties

Molecular Weight	839.96
Formula	C₄₂H₆₂O₁₆·NH₃
Cas No.	1407-03-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 155 mg/mL (184.5 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 5 mg/mL (5.95 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1905 mL	5.9527 mL	11.9053 mL	59.5266 mL
5 mM	0.2381 mL	1.1905 mL	2.3811 mL	11.9053 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1191 mL	0.5953 mL	1.1905 mL	5.9527 mL
20 mM	0.0595 mL	0.2976 mL	0.5953 mL	2.9763 mL
50 mM	0.0238 mL	0.1191 mL	0.2381 mL	1.1905 mL
100 mM	0.0119 mL	0.0595 mL	0.1191 mL	0.5953 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

53956-04-0Ammonium Glycyrrhizinate