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AMPK activator 4
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AMPK activator 4
Catalog No. T62238Cas No. 2493239-46-4
AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels and improves insulin resistance in db/db diabetic mice.AMPK activator 4 has hypoglycemic effects. activator 4 has hypoglycemic effects.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $83 | In Stock | |
| 5 mg | $193 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $626 | In Stock | |
| 50 mg | $892 | In Stock | |
| 100 mg | $1,220 | In Stock | |
| 500 mg | $2,430 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $226 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels and improves insulin resistance in db/db diabetic mice.AMPK activator 4 has hypoglycemic effects. activator 4 has hypoglycemic effects. |
| In vitro | AMPK activator 4 (compound B10) (10-20 μM; 72 h) slightly decreases the viability of HepG2 cells.[1] AMPK activator 4 (0-20 μM; 12-24 h) induced dose-dependent phosphorylation of ACC in C2C12 myotube cells, and the phosphorylation of ACC was highly consistent with the phosphorylation of AMPK. Increased the phosphorylation of AMPK and ACC in human hepatocarcinoma HepG2 and HuH-7 cells.[1] |
| In vivo | AMPK activator 4 (100 mg/kg; Intragastrical administration; daily for 9 weeks; db/db mice) significantly lowered the fasting blood glucose in db/db mice (2-6 weeks). Significantly improved insulin resistance in db/db mice (for 9 weeks). The body weight and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (two markers of liver injury) were not significantly affected. It shows an anti-hyperglycemic effect.[1] |
| Molecular Weight | 420.89 |
| Formula | C24H21ClN2O3 |
| Cas No. | 2493239-46-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (118.8 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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