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Antitumor agent-115
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Catalog No. T79580Cas No. 2759277-20-6
Antitumor agent-115 (SS-12) is a potent anti-tumor compound with an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].
Antitumor agent-115
😃Good
Catalog No. T79580Cas No. 2759277-20-6
Antitumor agent-115 (SS-12) is a potent anti-tumor compound with an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antitumor agent-115 (SS-12) is a potent anti-tumor compound with an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1]. |
| In vitro | Antitumor agent-115 (SS-12) primarily induces apoptosis in 4T1 cells by causing G0/G1 phase cell cycle arrest at 1.25 μM, 10 μM, and 40 μM concentrations over 24 hours [1]. At higher concentrations (15 μM, 30 μM, and 60 μM) for the same duration, it inhibits migration and invasion of 4T1 cells. Furthermore, at 10 μM over 24 hours, it induces apoptosis via the mitochondrial pathway [1]. |
| In vivo | Antitumor agent-115 (SS-12) exhibits high bioavailability in rats at a dose of 10 mg stachydrine/kg equivalent (200 μL, oral administration) and demonstrates antitumor activity in a mouse breast cancer model at a dosage of 0.1 mL/10 g (oral administration), improving the morphological structure of the spleen in these mice [1]. |
| Molecular Weight | 347.96 |
| Formula | C19H38ClNO2 |
| Cas No. | 2759277-20-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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