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Aranidipine

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Purity:98.85%

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COA HPLC HNMR

Aranidipine

Catalog No. T5376Cas No. 86780-90-7

Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$84	In Stock
25 mg	$153	In Stock
50 mg	$259	In Stock
100 mg	$437	In Stock

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Product Introduction

Bioactivity

Description	Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.
In vitro	In myocytes, aranidipine (10 nmol/l to 1 micromol/l) concentration-dependently decreased T-type and L-type Ca(2+) currents. Aranidipine (1 micromol/l) had little effect on K(+) currents. In the sinoatrial node, 0.1 micromol/l aranidipine increased cycle length and decreased +V(max) and the slope of the phase 4 depolarization [1].
In vivo	At 1 and 6 h after oral administration of MPC-1304 (10 mg/kg) in spontaneously hypertensive rats (SHR), there was significant decrease (48%) in the number of [3H](+)-PN 200-110 binding sites (Bmax) in myocardial membranes compared to control values. The in vivo specific binding of [3H](+)-PN 200-110 in particulate fractions of aorta of SHR was significantly reduced (74.8 and 37.9%, respectively) at 1 and 6 after oral administration of MPC-1304 (3 mg/kg), while the myocardial [3H](+)-PN 200-110 binding was decreased only at 1 h later [2].
Alias	MPC1304

Chemical Properties

Molecular Weight	388.37
Formula	C19H20N2O7
Cas No.	86780-90-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 22.5 mg/mL (57.93 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5749 mL	12.8743 mL	25.7486 mL	128.7432 mL
5 mM	0.5150 mL	2.5749 mL	5.1497 mL	25.7486 mL
10 mM	0.2575 mL	1.2874 mL	2.5749 mL	12.8743 mL
20 mM	0.1287 mL	0.6437 mL	1.2874 mL	6.4372 mL
50 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5749 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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