Shopping Cart
- Remove All
- Your shopping cart is currently empty
ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic arch and aorta, along with decreasing plasma ceramide concentrations and oxidized LDL (Ox-LDL) levels [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic arch and aorta, along with decreasing plasma ceramide concentrations and oxidized LDL (Ox-LDL) levels [1]. |
In vitro | ASM-IN-1 (compound 4i) does not affect cell growth in HUVEC [1]. At concentrations of 0, 1, and 5 µM, ASM-IN-1 reduces IL-6 and TNF-α expression in HUVEC in a dose-dependent manner upon LPS stimulation [1]. Moreover, at 5 µM, ASM-IN-1 decreases MCP-1 mRNA expression and normalizes IL-6 mRNA levels in the presence of Ox-LDL [1]. |
In vivo | ASM-IN-1, administered via intravenous injection at 1 mg/kg and orally at 10 mg/kg, demonstrated favorable pharmacokinetic properties in ICR mice with an oral bioavailability of 35.42% [1]. When given intraperitoneally at doses of 6, 12, and 40 mg/kg twice daily for a duration of 8 weeks, ASM-IN-1 exhibited anti-atherosclerotic activity by inhibiting ASM activity in mice [1]. |
Molecular Weight | 390.19 |
Formula | C16H12BrN3O4 |
Cas No. | 2913151-46-7 |
Storage | Shipping with blue ice. |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.