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ASM-IN-3

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Catalog No. T203687Cas No. 2342576-75-2

ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.

ASM-IN-3

ASM-IN-3

😃Good
Catalog No. T203687Cas No. 2342576-75-2
ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.
In vitro
ASM-IN-3 effectively penetrates hCMEC/D3 cell membranes at concentrations of 40 μM within 0.5 to 4 hours. It is also safe for NIH3T3 cells, with an IC 50 value of 161 μM, when used in concentrations ranging from 0.098 to 12.5 μM.
In vivo
ASM-IN-3 (48 mg/kg, intraperitoneal injection) effectively penetrates the blood-brain barrier in SD rats, as its concentration in brain tissue is significantly higher than in plasma. Additionally, ASM-IN-3 (6-24 mg/kg, intravenous injection, twice daily for 2 weeks) exhibits notable antidepressant-like effects in reserpine-induced depressed rats by reducing ASM activity in the hippocampus and restoring neurogenesis.
Chemical Properties
Molecular Weight344.75
FormulaC17H13ClN2O4
Cas No.2342576-75-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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