Shopping Cart
- Remove All
- Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $123 | In Stock | |
5 mg | $263 | In Stock | |
10 mg | $393 | In Stock | |
25 mg | $646 | In Stock | |
50 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $288 | In Stock |
Description | Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2]. |
Targets&IC50 | Cathepsin L:12 μM, Cathepsin B:49 μM |
In vitro | Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively. |
In vivo | Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling. |
Alias | Asperglaucide |
Molecular Weight | 444.52 |
Formula | C27H28N2O4 |
Cas No. | 56121-42-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (123.73 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.