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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $59 | In Stock | |
5 mg | $132 | In Stock | |
10 mg | $193 | In Stock | |
25 mg | $423 | In Stock | |
50 mg | $627 | In Stock | |
100 mg | $893 | In Stock | |
1 mL x 10 mM (in DMSO) | $166 | In Stock |
Description | AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research. |
In vitro | AZ31 (0.3-3 μM ; 1 h) modulates the phosphorylation of a range of ATM targets.[2] AZ31 (10 μM ; 1 h) influences the stabilization of p53 in H2228 lung cancer cells post-radiation.[2] |
In vivo | AZ31 (50-100 mg/kg ; p.o. twice daily) exhibits limited penetration into the brain.[2] |
Alias | AZ 31, AZ-31 |
Molecular Weight | 420.5 |
Formula | C24H28N4O3 |
Cas No. | 2088113-98-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (59.45 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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