Shopping Cart
- Remove All
Your shopping cart is currently empty
BAL-0028
🥰Excellent
Catalog No. T85341Cas No. 2842012-69-3
Alias BAL0028, BAL 0028
BAL-0028 is a potent inhibitor of NLRP3 activation (IC50: 25 nM) with anti-inflammatory activity for cancer research.
BAL-0028
🥰Excellent
Purity: 99.16%
Catalog No. T85341Alias BAL0028, BAL 0028Cas No. 2842012-69-3
BAL-0028 is a potent inhibitor of NLRP3 activation (IC50: 25 nM) with anti-inflammatory activity for cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,970 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "BAL-0028"
NLRP3-IN-2
NLRP3 Inflammasome Inhibitor I, 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide
T323016673-34-0
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting infarct size after myocardial ischemia/reperfusion in mice and has no effect on metabolism.
- $41
Size
QTY
MCC950 sodium
Cited
CRID3 sodium salt, CP-456773 sodium
T6887256373-96-3
MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs). MCC950 sodium has no effect on other inflammatory vesicles such as AIM2, NLRC4 or NLRP1.
- $30
Size
QTY
CitedBergenin
Cuscutin, Bengenin
T0122477-90-7
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
- $50
Size
QTY
Imperatorin
Pentosalen, Marmelosin, Ammidin, 8-Isopentenyloxypsoralene, 8-Isoamylenoxypsoralen
T2845482-44-0
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
- $41
Size
QTY
Dapansutrile Cited
T1505254863-37-5
Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
- $41
Size
QTY
CitedSelnoflast
RO-7486967, RG 6418
T617862260969-36-4In house
Selnoflast (example 6) is a NLRP3 inhibitor[1].
- $132
Size
QTY
NLRP3-IN-9
INF-4E, INF4E, INF 4E
T2817888039-46-7
NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
- $35
Size
QTY
NOD-IN-1
Compound 4
T3587132819-92-2
NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
- $68
Size
QTY
Nigericin sodium salt Cited
T309228643-80-3
Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-positive bacteria.
- $31
Size
QTY
CitedNLRP3-IN-10
ZVN26391
T613922641826-39-1
NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome.
- $39
Size
QTY
Select Batch
Purity:99.16%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BAL-0028 is a potent inhibitor of NLRP3 activation (IC50: 25 nM) with anti-inflammatory activity for cancer research. |
| Targets&IC50 | NLRP3:25 nM |
| In vitro | A series of novel high-affinity, reversible inhibitors of NLRP3 activation were discovered by screening a DNA-encoded library, and a potent lead compound, BAL-0028, was identified directly from the screen with an IC50 value of 25 nM; SPR studies showed that BAL-0028 binds tightly to the NACHT domain of NLRP3 (KD range of 104-123 nM); CADD analysis of the interaction of BAL-0028 with the NLRP3 NACHT domain showed that the binding site is distinct from that of ADP and MCC950 and includes site-specific interactions. [1] |
| Alias | BAL0028, BAL 0028 |
| Molecular Weight | 403.45 |
| Formula | C24H22FN3O2 |
| Cas No. | 2842012-69-3 |
| Smiles | O=C(C=1C=CC(=C(OCC)C1)C2=CC=CC(F)=C2)N(C)CC3=CC=CC=4C=NNC43 |
| Relative Density. | 1.256 g/cm3 at 20℃ (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy BAL-0028 | purchase BAL-0028 | BAL-0028 cost | order BAL-0028 | BAL-0028 chemical structure | BAL-0028 in vitro | BAL-0028 formula | BAL-0028 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.