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Brilliant Black BN
🥰Excellent
Catalog No. T18928Cas No. 2519-30-4
Alias E 151
Brilliant Black BN (E 151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.
Brilliant Black BN
🥰Excellent
Catalog No. T18928Alias E 151Cas No. 2519-30-4
Brilliant Black BN (E 151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $48 | In Stock | |
| 50 mg | $68 | In Stock | |
| 100 mg | $98 | In Stock | |
| 200 mg | $148 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Brilliant Black BN (E 151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. |
| Targets&IC50 | EV71 (various strains):2.39 µM- 28.12 µM (IC50) |
| In vitro | Brilliant black BN inhibited the infection EV71 -GFP at a concentration of 300 μM. Brilliant black BN exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells (IC50: 10.1 μM). Brilliant black BN is able to inhibit all tested 28 EV71, CVA16, and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 μM to 28.12 μM, whereas its 50% cytotoxic concentration is 1870 μM [2]. |
| In vivo | Brilliant black BN (i.p.; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group. All E151 270 treated mice are completely protected throughout the experiment [2]. |
| Alias | E 151 |
| Molecular Weight | 867.68 |
| Formula | C28H17N5Na4O14S4 |
| Cas No. | 2519-30-4 |
| Smiles | [Na+].[Na+].[Na+].[Na+].CC(=O)Nc1ccc(c2cc(c(\N=N\c3ccc(\N=N\c4ccc(cc4)S(=O)(=O)[O-])c5ccc(cc35)S(=O)(=O)[O-])c(O)c12)S(=O)(=O)[O-])S(=O)(=O)[O-] |
| Relative Density. | 0.513 g/cm3. Temperature:33.4 °C.;0.627 g/cm3. Temperature:33.4 °C. |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 123 mg/mL (141.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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