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CCT020312

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Purity:98.36%

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COA LCMS HPLC HNMR

CCT020312

Catalog No. T14902Cas No. 324759-76-4

CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.

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Pack Size	Price	Availability
1 mg	$63	In Stock
5 mg	$146	In Stock
10 mg	$255	In Stock
25 mg	$429	In Stock
50 mg	$635	In Stock
100 mg	$883	In Stock
500 mg	$1,830	In Stock

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Product Introduction

Bioactivity

Description	CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.
In vitro	In HT29 cells, CCT020312 reduces the P-S608-pRB signal with a linear response between 1.8 and 6.1 μM in a concentration-dependent manner. CCT020312(10 μM) decreases G1/S cyclins D1, D2, E, and A, reduces the CDK catalytic subunit CDK2 and increased the level of the p27KIP1[1].
In vivo	In wild-type mice, intraperitoneal injection of CCT020312 (1-5 mg/kg) increases PERK and NRF2 phosphorylation of brain homogenates. In P301S tau transgenic mice, intraperitoneal injection of CCT020312 (2 mg/kg) behaves better in the Morris water maze test[2].

Chemical Properties

Molecular Weight	650.4
Formula	C31H30Br2N4O2
Cas No.	324759-76-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (138.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5375 mL	7.6876 mL	15.3752 mL	76.8758 mL
5 mM	0.3075 mL	1.5375 mL	3.0750 mL	15.3752 mL
10 mM	0.1538 mL	0.7688 mL	1.5375 mL	7.6876 mL
20 mM	0.0769 mL	0.3844 mL	0.7688 mL	3.8438 mL
50 mM	0.0308 mL	0.1538 mL	0.3075 mL	1.5375 mL
100 mM	0.0154 mL	0.0769 mL	0.1538 mL	0.7688 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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