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CCT020312
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Catalog No. T14902Cas No. 324759-76-4
CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 µM.
CCT020312
🥰Excellent
Purity: 98.36%
Catalog No. T14902Cas No. 324759-76-4
CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 µM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $56 | In Stock | |
| 5 mg | $143 | In Stock | |
| 10 mg | $253 | In Stock | |
| 25 mg | $429 | In Stock | |
| 50 mg | $635 | In Stock | |
| 100 mg | $883 | In Stock | |
| 500 mg | $1,830 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | In Stock |
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Purity:98.36%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 µM. |
| In vitro | METHODS: CCT020312 (0-9 µM, 24 h) treated medium HT29 cells for 24 h. Ser608 pRB phosphorylation was quantified using a cell-based immunoassay. RESULTS Concentration-dependent loss of P-S608-pRB signaling was observed with linear response values between 1.8 and 6.1 µM. [1] |
| In vivo | METHODS: CCT020312 (2 mg/kg, intraperitoneal injection, starting at 17 weeks for 6 weeks) was used to treat P301S tau transgenic mice to test for mouse-specific visuospatial memory deficits. RESULTS P301S tau transgenic mice performed significantly better in the Morris water maze. [2] |
| Molecular Weight | 650.4 |
| Formula | C31H30Br2N4O2 |
| Cas No. | 324759-76-4 |
| Smiles | CCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O |
| Relative Density. | 1.48 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (138.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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