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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $63 | In Stock | |
5 mg | $146 | In Stock | |
10 mg | $255 | In Stock | |
25 mg | $429 | In Stock | |
50 mg | $635 | In Stock | |
100 mg | $883 | In Stock | |
500 mg | $1,830 | In Stock |
Description | CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A. |
In vitro | In HT29 cells, CCT020312 reduces the P-S608-pRB signal with a linear response between 1.8 and 6.1 μM in a concentration-dependent manner. CCT020312(10 μM) decreases G1/S cyclins D1, D2, E, and A, reduces the CDK catalytic subunit CDK2 and increased the level of the p27KIP1[1]. |
In vivo | In wild-type mice, intraperitoneal injection of CCT020312 (1-5 mg/kg) increases PERK and NRF2 phosphorylation of brain homogenates. In P301S tau transgenic mice, intraperitoneal injection of CCT020312 (2 mg/kg) behaves better in the Morris water maze test[2]. |
Molecular Weight | 650.4 |
Formula | C31H30Br2N4O2 |
Cas No. | 324759-76-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (138.4 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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