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Conopeptide rho-TIA
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Catalog No. T80175Cas No. 381725-58-2
Conopeptide rho-TIA, a peptide from Conus tulipa venom, acts as a selective, noncompetitive inhibitor at the human α1B-Adrenergic Receptor and as a competitive inhibitor at the α1A and α1D-Adrenergic Receptors. Binding to these subtypes, conopeptide rho-TIA may inform the creation of new α1-Adrenergic Receptor subtype-selective drugs [1].
Conopeptide rho-TIA
😃Good
Catalog No. T80175Cas No. 381725-58-2
Conopeptide rho-TIA, a peptide from Conus tulipa venom, acts as a selective, noncompetitive inhibitor at the human α1B-Adrenergic Receptor and as a competitive inhibitor at the α1A and α1D-Adrenergic Receptors. Binding to these subtypes, conopeptide rho-TIA may inform the creation of new α1-Adrenergic Receptor subtype-selective drugs [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | Conopeptide rho-TIA, a peptide from Conus tulipa venom, acts as a selective, noncompetitive inhibitor at the human α1B-Adrenergic Receptor and as a competitive inhibitor at the α1A and α1D-Adrenergic Receptors. Binding to these subtypes, conopeptide rho-TIA may inform the creation of new α1-Adrenergic Receptor subtype-selective drugs [1]. |
| In vitro | Conopeptide rho-TIA at a concentration of 100 nM applied for 24-48 hours interacts with human α1B-Adrenergic Receptor non-competitively and reversibly, suggesting its potential role as an allosteric inhibitor [1]. At 30 nM for 2 hours, conopeptide rho-TIA acts as a non-competitive inhibitor for the α1B-Adrenergic Receptor but competitively inhibits the α1A and α1D-Adrenergic Receptor subtypes [1]. Additionally, a single application of 10 μM conopeptide rho-TIA inhibits the increase in cytoplasmic Ca2+ concentration mediated by the α1-Adrenergic Receptor activation by norepinephrine, without affecting the presynaptic α2-Adrenergic Receptor-mediated responses [2]. |
| Molecular Weight | 2390.88 |
| Formula | C105H160N36O21S4 |
| Cas No. | 381725-58-2 |
Storage & Solubility Information
| Storage | keep away from moisture | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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