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COX-2-IN-2

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Purity:98.85%

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COA HNMR LCMS

COX-2-IN-2

Catalog No. T10032Cas No. 134729-13-8

COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.

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Pack Size	Price	Availability
1 mg	$497	In Stock
5 mg	$987	In Stock
10 mg	$1,360	In Stock
25 mg	$1,980	In Stock
50 mg	$2,710	In Stock
100 mg	$3,670	In Stock
1 mL x 10 mM (in DMSO)	$1,090	In Stock

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Product Introduction

Bioactivity

Description	COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.
Targets&IC50	COX-2:240 nM
In vitro	COX-2-IN-2 demonstrates no inhibition of COX-1, even at a concentration of 100μM[1].
In vivo	COX-2-IN-2 exhibits oral ED50 values of 0.030 mg/kg for adjuvant-induced arthritis and 0.47 mg/kg for collagen-induced arthritis, with an ED30 of 7.4 mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay, demonstrating good analgesic activity and no ulcerogenicity[1].

Chemical Properties

Molecular Weight	341.36
Formula	C17H12FN3O2S
Cas No.	134729-13-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (131.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9295 mL	14.6473 mL	29.2946 mL	146.4729 mL
5 mM	0.5859 mL	2.9295 mL	5.8589 mL	29.2946 mL
10 mM	0.2929 mL	1.4647 mL	2.9295 mL	14.6473 mL
20 mM	0.1465 mL	0.7324 mL	1.4647 mL	7.3236 mL
50 mM	0.0586 mL	0.2929 mL	0.5859 mL	2.9295 mL
100 mM	0.0293 mL	0.1465 mL	0.2929 mL	1.4647 mL

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