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COX-2-IN-2
Catalog No. T10032Cas No. 134729-13-8
COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.
COX-2-IN-2
Catalog No. T10032Cas No. 134729-13-8
COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $497 | In Stock | |
| 5 mg | $987 | In Stock | |
| 10 mg | $1,360 | In Stock | |
| 25 mg | $1,980 | In Stock | |
| 50 mg | $2,710 | In Stock | |
| 100 mg | $3,670 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $1,090 | In Stock |
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CitedSelect Batch
Purity:98.85%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities. |
| Targets&IC50 | COX-2:240 nM |
| In vitro | COX-2-IN-2 demonstrates no inhibition of COX-1, even at a concentration of 100μM[1]. |
| In vivo | COX-2-IN-2 exhibits oral ED50 values of 0.030 mg/kg for adjuvant-induced arthritis and 0.47 mg/kg for collagen-induced arthritis, with an ED30 of 7.4 mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay, demonstrating good analgesic activity and no ulcerogenicity[1]. |
| Molecular Weight | 341.36 |
| Formula | C17H12FN3O2S |
| Cas No. | 134729-13-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (131.83 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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