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COX-2-IN-34
Catalog No. T77618Cas No. 2788578-71-0
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
COX-2-IN-34
Catalog No. T77618Cas No. 2788578-71-0
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $430 | In Stock | |
| 10 mg | $636 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,360 | In Stock | |
| 100 mg | $1,830 | In Stock | |
| 500 mg | $3,680 | In Stock |
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Purity:98.08%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice. |
| Targets&IC50 | COX-2:0.42 μM, COX-1:34.86 μM |
| In vitro | COX-2-IN-34 (compound 8a) (100 μM, 24 h) shows no significant cytotoxicity on RAW264.7 cells.[1] It selectively inhibits COX-1 and COX-2 activities with IC50 values of 34.86 and 0.42 μM, respectively, and at 10 μM, inhibits COX-2 by 82%.[1] |
| In vivo | COX-2-IN-34 (compound 8a) (50 mg/kg; orally; 3 days; rats) exhibits no gastric ulcer toxicity in a normal male rat model. COX-2-IN-34 (50 mg/kg; s.c.; rats) shows significant reduction in edema claw volume at 0, 1, 2, 3, 4, and 6 hours post-carrageenan injection compared to the control, with 42.90% and 45.95% inhibition at the 3rd and 4th hour, respectively, closely matching Celecoxib's 45.18% inhibition at 3 hours, demonstrating significant anti-inflammatory effects in carrageenan-induced plantar edema in rats.[1] |
| Molecular Weight | 245.23 |
| Formula | C13H11NO4 |
| Cas No. | 2788578-71-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (183.5 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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