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CPCCOEt
Catalog No. T22692Cas No. 179067-99-3
CPCCOEt is a low-affinity, selective, non-competitive, and reversible antagonist of mGluR1b.
CPCCOEt
Catalog No. T22692Cas No. 179067-99-3
CPCCOEt is a low-affinity, selective, non-competitive, and reversible antagonist of mGluR1b.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $48 | In Stock | |
| 10 mg | $67 | In Stock | |
| 25 mg | $136 | In Stock | |
| 50 mg | $223 | In Stock | |
| 100 mg | $329 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CPCCOEt is a low-affinity, selective, non-competitive, and reversible antagonist of mGluR1b. |
| Targets&IC50 | mGluR1b (human):6.5 μM |
| In vitro | CPCCOEt selectively inhibited glutamate-induced increases in intracellular calcium at human mGluR1b (hmGluR1b) with an apparent IC50 of 6.5 μM while having no agonist or antagonist activity at hmGluR2, -4a, -5a, -7b, and -8a up to 100 μM. In addition, introduction of Thr815 and Ala818 at the homologous positions of hmGluR5a conferred complete inhibition by CPCCOEt (IC50 = 6.6 μM)[1]. |
| In vivo | Whole-cell voltage recording from Purkinje cells in slices of rat cerebellum showed that CPCCOEt enhanced the climbing fiber response at concentrations of blocking the mGlu1 receptor(100 μM)[2]. |
| Molecular Weight | 247.25 |
| Formula | C13H13NO4 |
| Cas No. | 179067-99-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (364.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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