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Cytosporone B
Catalog No. T3976Cas No. 321661-62-5
Alias Dothiorelone G, Csn-B
Cytosporone B (Dothiorelone G) is a naturally occurring agonist of the nuclear orphan receptor Nur77/NR4A1 (EC50=0.278 nM).
Cytosporone B
Catalog No. T3976Alias Dothiorelone G, Csn-BCas No. 321661-62-5
Cytosporone B (Dothiorelone G) is a naturally occurring agonist of the nuclear orphan receptor Nur77/NR4A1 (EC50=0.278 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $39 | In Stock | |
| 5 mg | $59 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $197 | In Stock | |
| 50 mg | $317 | In Stock | |
| 100 mg | $469 | In Stock | |
| 500 mg | $1,050 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock |
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Purity:98.85%
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Bioactivity
Chemical Properties
| Description | Cytosporone B (Dothiorelone G) is a naturally occurring agonist of the nuclear orphan receptor Nur77/NR4A1 (EC50=0.278 nM). |
| Targets&IC50 | Nur77:0.278 nM |
| In vitro | Cytosporone B targets the ligand-binding domain of Nur77, Cytosporone B induced fluorokinase activity in cells cotransfected with GAL4-Nur77 or GAL4-LBD, the EC50 of Cytosporone B for Nur77 is 0.278 nM. Cytosporone B had an inhibitory effect on the proliferation of human cancer BGC- 823 cells and human cancer SW620 cells by greater than 70%, but had modest inhibitory effect on human cancer H1299 cells and human hepatocellular carcinoma HepG2 cells by greater than or equal to 40%. [1] |
| In vivo | In wild-type mice, Cytosporone B treatment significantly increased glucose levels from 3.2 mM to 11.4 mM within the first 30 minutes, after which blood glucose gradually decreased, reaching initial levels after 300 minutes. [1] |
| Alias | Dothiorelone G, Csn-B |
| Molecular Weight | 322.4 |
| Formula | C18H26O5 |
| Cas No. | 321661-62-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (139.58 mM)  2% DMSO＋98% (20% SBE-β-CD in Saline): 2 mg/mL, Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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