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Product Introduction

Bioactivity

Description	D-Glutamic acid ((R)-Glutamic acid), the enantiomer of L-glutamic acid, is widely used in medicine and food.
In vitro	Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu), are widely found in mammals, including humans, and are considered candidate new physiologically active substances and/or biomarkers. D-[Asp/Glu] (4 mg/mL) inhibited the binding of IgE to peanuts (75%), while D-Glu and D-Asp had no inhibitory effect. IgE is specific to D-[Asp/Glu] and may have the potential to remove IgE or reduce its binding to peanut allergens.
In vivo	At present, D-glutamic acid is receiving attention as a regulator of neuronal transmission and hormone secretion. It is only metabolized by D-aspartate oxidase in mammals. After intraperitoneal injection, L-glutamic acid is catabolized by α-ketoglutarate, and D-glutamic acid is converted to n-pyrrolidone carboxylic acid. The carbon 2 of D- and L-glutamic acid is converted to methyl acetate in the cecum. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid.
Alias	(R)-Glutamic acid

Chemical Properties

Molecular Weight	147.13
Formula	C₅H₉NO₄
Cas No.	6893-26-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 10 mg/mL (67.97 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.7967 mL	33.9836 mL	67.9671 mL	339.8355 mL
5 mM	1.3593 mL	6.7967 mL	13.5934 mL	67.9671 mL
10 mM	0.6797 mL	3.3984 mL	6.7967 mL	33.9836 mL
20 mM	0.3398 mL	1.6992 mL	3.3984 mL	16.9918 mL
50 mM	0.1359 mL	0.6797 mL	1.3593 mL	6.7967 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Endogenous MetaboliteInhibitorGlutamic acidDGlutamic acidD Glutamic acidD-Glutamic acidinhibit