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Daun02
😃Good
Catalog No. T15054Cas No. 290304-24-4
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
Daun02
😃Good
Catalog No. T15054Cas No. 290304-24-4
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $747 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Daun02 is the topoisomerase inhibitor Daunorubicin prodrug. |
| In vitro | Daun02 is converted by β-galactosidase to Daunorubicin, which has been shown to reduce Ca2+-dependent action potentials in neuroblastoma cells [1]. Daun02 is a good substrate for β-galactosidase (β-gal) and it also is a topoisomerase inhibitor [2]. The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively [3]. |
| In vivo | Daun02 is an efficient substrate for β-gal (Km: 0.37 mM; Vmax: 8.6 μmol/min/mg). It demonstrates 79% plasma protein binding, compared to 94% for Daunomycin at 10 μM [3]. |
| Molecular Weight | 884.79 |
| Formula | C41H44N2O20 |
| Cas No. | 290304-24-4 |
| Relative Density. | 1.67 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (113.02 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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