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Daun02

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Daun02

Catalog No. T15054Cas No. 290304-24-4

Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.

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Pack Size	Price	Availability	Quantity
25 mg	$747	Backorder

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Product Introduction

Bioactivity

Description	Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
In vitro	Daun02 is converted by β-galactosidase to Daunorubicin, which has been shown to reduce Ca2+-dependent action potentials in neuroblastoma cells [1]. Daun02 is a good substrate for β-galactosidase (β-gal) and it also is a topoisomerase inhibitor [2]. The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively [3].
In vivo	Daun02 is an efficient substrate for β-gal (Km: 0.37 mM; Vmax: 8.6 μmol/min/mg). It demonstrates 79% plasma protein binding, compared to 94% for Daunomycin at 10 μM [3].

Chemical Properties

Molecular Weight	884.79
Formula	C41H44N2O20
Cas No.	290304-24-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (113.02 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1302 mL	5.6511 mL	11.3021 mL	56.5106 mL
5 mM	0.2260 mL	1.1302 mL	2.2604 mL	11.3021 mL
10 mM	0.1130 mL	0.5651 mL	1.1302 mL	5.6511 mL
20 mM	0.0565 mL	0.2826 mL	0.5651 mL	2.8255 mL
50 mM	0.0226 mL	0.1130 mL	0.2260 mL	1.1302 mL
100 mM	0.0113 mL	0.0565 mL	0.1130 mL	0.5651 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Daun02Daun-02

Daun02

Daun02

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