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Demcizumab
Catalog No. T76788Cas No. 1243262-17-0
Alias OMP 21M18
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.
Demcizumab
Demcizumab
Catalog No. T76788Alias OMP 21M18Cas No. 1243262-17-0
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $372 | In Stock | |
| 5 mg | $933 | In Stock | |
| 10 mg | $1,490 | In Stock |
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DAPT Cited
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gamma-secretase modulator 1
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FLI-06
FLI 06
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IMR-1A Cited
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IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
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CitedSelect Batch
Concentration:5.82 mg/mL
Purity:> 95%
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents. |
| In vitro | Demcizumab (0-100 μg/mL) specifically binds to human DLL4, blocking its interaction with the Notch1 receptor in FACS binding assays[3]. Treatment with Demcizumab at 20 μg/mL for 48 hours reduces HES1 and DTX1 mRNA expression in PDTALL cells[4]. Additionally, Demcizumab (0-80 μg/mL, 1, 2, or 3 days) induces cell death and early apoptosis in PDTALL13 cells[4]. |
| In vivo | Demcizumab (10 mg/kg, i.p., once weekly) combined with Irinotecan (7.5 mg/kg) shows substantial antitumor activity in KRASWT and KRASMT colorectal cancer xenograft models[2]. Demcizumab, both as monotherapy or with Irinotecan (7.5 mg/kg), is effective against OMP-C8 colon tumors[3]. Administration of Demcizumab (20 mg/kg/week, intraperitoneal injection) enhances the survival rate of NRG mice injected with irradiated PDTALL13 cells[4]. |
| Alias | OMP 21M18 |
| Molecular Weight | 145.34 kDa |
| Cas No. | 1243262-17-0 |
Storage & Solubility Information
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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