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Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | Inquiry | In Stock | |
5 mg | $42 | In Stock | |
10 mg | $59 | In Stock | |
25 mg | $118 | In Stock | |
50 mg | $193 | In Stock | |
100 mg | $286 | In Stock | |
200 mg | $426 | In Stock |
Description | Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections. |
Targets&IC50 | SFL3 strain co-cultivated with Trypanosoma cruzi:2.5 μg/ml (MIC), BYso strain co-cultivated with bacteria:2.5 μg/ml (MIC), SFL3 strain cultured aseptically:1.95 μg/ml (MIC) |
In vitro | Diloxanide furoate showed significant activity against different strains of Tissue Lysing Ameba in the concentration range of 1.95 to 2.5 μg/ml. The minimum inhibitory concentration (MIC) was 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml for BYso strain co-cultivated with bacteria, SFL3 strain co-cultivated with Trypanosoma cruzi and SFL3 strain cultured aseptically. [1] |
In vivo | Diloxanide furoate administered orally at doses ranging from 75-200 mg/kg once daily for 3 consecutive days showed efficacy in weanling pups at different doses. Administered at a dose of 200 mg/kg, 100% of the subject rats were cured and no amebic lesions were observed in the cecum. In addition, the cure rate was 85%, 77% and 44.4% when administered at doses of 150 mg/kg, 100 mg/kg and 75 mg/kg, respectively. The half effective dose (ED50) of the drug in rats was 77.9 mg/kg. [1] |
Alias | Diloxanide, Dichlofurazol, Amebamide |
Molecular Weight | 328.15 |
Formula | C14H11Cl2NO4 |
Cas No. | 3736-81-0 |
Smiles | O=C(OC1=CC=C(C=C1)N(C(=O)C(Cl)Cl)C)C=2OC=CC2 |
Relative Density. | 1.424 g/cm3 (Predicted) |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 10 mg/mL (30.47 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) DMSO: 40 mg/mL (121.9 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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