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Diloxanide furoate

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Catalog No. T15131Cas No. 3736-81-0
Alias Diloxanide, Dichlofurazol, Amebamide

Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.

Diloxanide furoate

Diloxanide furoate

🥰Excellent
Catalog No. T15131Alias Diloxanide, Dichlofurazol, AmebamideCas No. 3736-81-0
Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.
Pack SizePriceAvailabilityQuantity
1 mgInquiryIn Stock
5 mg$42In Stock
10 mg$59In Stock
25 mg$118In Stock
50 mg$193In Stock
100 mg$286In Stock
200 mg$426In Stock
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Product Introduction

Bioactivity
Description
Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.
Targets&IC50
SFL3 strain co-cultivated with Trypanosoma cruzi:2.5 μg/ml (MIC), BYso strain co-cultivated with bacteria:2.5 μg/ml (MIC), SFL3 strain cultured aseptically:1.95 μg/ml (MIC)
In vitro
Diloxanide furoate showed significant activity against different strains of Tissue Lysing Ameba in the concentration range of 1.95 to 2.5 μg/ml. The minimum inhibitory concentration (MIC) was 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml for BYso strain co-cultivated with bacteria, SFL3 strain co-cultivated with Trypanosoma cruzi and SFL3 strain cultured aseptically. [1]
In vivo
Diloxanide furoate administered orally at doses ranging from 75-200 mg/kg once daily for 3 consecutive days showed efficacy in weanling pups at different doses. Administered at a dose of 200 mg/kg, 100% of the subject rats were cured and no amebic lesions were observed in the cecum. In addition, the cure rate was 85%, 77% and 44.4% when administered at doses of 150 mg/kg, 100 mg/kg and 75 mg/kg, respectively. The half effective dose (ED50) of the drug in rats was 77.9 mg/kg. [1]
AliasDiloxanide, Dichlofurazol, Amebamide
Chemical Properties
Molecular Weight328.15
FormulaC14H11Cl2NO4
Cas No.3736-81-0
SmilesO=C(OC1=CC=C(C=C1)N(C(=O)C(Cl)Cl)C)C=2OC=CC2
Relative Density.1.424 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 10 mg/mL (30.47 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
DMSO: 40 mg/mL (121.9 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.0474 mL15.2369 mL30.4739 mL152.3693 mL
5 mM0.6095 mL3.0474 mL6.0948 mL30.4739 mL
10 mM0.3047 mL1.5237 mL3.0474 mL15.2369 mL
20 mM0.1524 mL0.7618 mL1.5237 mL7.6185 mL
DMSO
1mg5mg10mg50mg
50 mM0.0609 mL0.3047 mL0.6095 mL3.0474 mL
100 mM0.0305 mL0.1524 mL0.3047 mL1.5237 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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