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Diloxanide furoate
Catalog No. T15131Cas No. 3736-81-0
Alias Diloxanide, Dichlofurazol, Amebamide
Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.
Diloxanide furoate
Catalog No. T15131Alias Diloxanide, Dichlofurazol, AmebamideCas No. 3736-81-0
Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | In Stock | |
| 5 mg | $42 | In Stock | |
| 10 mg | $59 | In Stock | |
| 25 mg | $118 | In Stock | |
| 50 mg | $193 | In Stock | |
| 100 mg | $286 | In Stock | |
| 200 mg | $426 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections. |
| Targets&IC50 | BYso strain co-cultivated with bacteria:2.5 μg/ml (MIC), SFL3 strain cultured aseptically:1.95 μg/ml (MIC), SFL3 strain co-cultivated with Trypanosoma cruzi:2.5 μg/ml (MIC) |
| In vitro | Diloxanide furoate showed significant activity against different strains of Tissue Lysing Ameba in the concentration range of 1.95 to 2.5 μg/ml. The minimum inhibitory concentration (MIC) was 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml for BYso strain co-cultivated with bacteria, SFL3 strain co-cultivated with Trypanosoma cruzi and SFL3 strain cultured aseptically. [1] |
| In vivo | Diloxanide furoate administered orally at doses ranging from 75-200 mg/kg once daily for 3 consecutive days showed efficacy in weanling pups at different doses. Administered at a dose of 200 mg/kg, 100% of the subject rats were cured and no amebic lesions were observed in the cecum. In addition, the cure rate was 85%, 77% and 44.4% when administered at doses of 150 mg/kg, 100 mg/kg and 75 mg/kg, respectively. The half effective dose (ED50) of the drug in rats was 77.9 mg/kg. [1] |
| Alias | Diloxanide, Dichlofurazol, Amebamide |
| Molecular Weight | 328.15 |
| Formula | C14H11Cl2NO4 |
| Cas No. | 3736-81-0 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 10 mg/mL (30.47 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble)  DMSO: 40 mg/mL (121.9 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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