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Dipyrithione

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Purity:99.86%

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COA HPLC HNMR

Dipyrithione

Catalog No. T7969Cas No. 3696-28-4

Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity

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Pack Size	Price	Availability
10 mg	$31	In Stock
25 mg	$48	In Stock
50 mg	$70	In Stock
100 mg	$98	In Stock
200 mg	$148	In Stock
500 mg	$252	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity
In vitro	Dipyrithione(PTS2) inhibited proliferation in four cancer cell lines in a dose-dependent manner. Treated cells showed shrinkage, irregular fragments, condensed and dispersed blue fluorescent particles compared with control cells. PTS2 induced cycle-arrest and death. Cleavage of caspase-9, caspase-3, and PARP were detected in PTS2-treated cells. Antitumor activity of PTS2 was more effective against widely used cancer drugs and its precursor[1].
Cell Research	Used MTT assays and trypan blue staining to test the viability of cancer cell lines. Hoechst 33258 and DAPI staining were used to observe cell apoptosis. Cell-cycle percentages were analyzed by flow cytometry. Apoptosis was assayed using caspase-3 and poly (ADP-ribose) polymerase (PARP) combined with Western blotting. Student's t-test was used for statistical analysis[1].

Chemical Properties

Molecular Weight	252.31
Formula	C10H8N2O2S2
Cas No.	3696-28-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.52 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9634 mL	19.8169 mL	39.6338 mL	198.1689 mL
5 mM	0.7927 mL	3.9634 mL	7.9268 mL	39.6338 mL

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In Vivo Formulation Calculator (Clear solution)

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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