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DPTN dihydrochloride

🥰Excellent
Catalog No. T72067Cas No. 325767-87-1

DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively.

DPTN dihydrochloride

DPTN dihydrochloride

🥰Excellent
Purity: 100%
Catalog No. T72067Cas No. 325767-87-1
DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$43In Stock
5 mg$98In Stock
10 mg$168In Stock
25 mg$365In Stock
50 mg$562In Stock
100 mg$790In Stock
500 mg$1,670In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively.
Targets&IC50
A3 (human):1.65 nM (Ki)
In vitro
DPTN dihydrochloride is a potent antagonist of human, mouse, and rat A3AR. However, compared with human A3AR, DPTN dihydrochloride has a weaker effect and reduced selectivity in mice and rats (approximately 20 times that of A2BAR).[1]
The binding affinity test of DNPT (10 μM) on the cell membrane of transfected HEK293 cells showed that its Ki values for hA1, hA2A, hA2B and hA3 were 162±49, 121±42, 230±40 and 1.65±0.57 nM respectively[ 1]. The Ki values of DPTN dihydrochloride at A1, A2A, A2B and A3 receptors are 411, 830, 189 and 9.61 nM (mouse); 333, 1147, 163 and 8.53 nM (rat) respectively.[1]
Chemical Properties
Molecular Weight459.39
FormulaC22H20Cl2N4OS
Cas No.325767-87-1
SmilesO=C(C1=CC=CN=C1)NC2=NC(C3=CC(C)=CC(C)=C3)=C(C4=CC=NC=C4)S2.Cl.Cl
Relative Density.no data available
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 2.30 mg/mL (5 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1768 mL10.8840 mL21.7680 mL108.8400 mL
5 mM0.4354 mL2.1768 mL4.3536 mL21.7680 mL

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