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DuP-697

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Purity:100%

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COA HPLC HNMR

DuP-697

Catalog No. T15181Cas No. 88149-94-4

DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects.

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Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$198	In Stock
10 mg	$323	In Stock
25 mg	$553	In Stock
50 mg	$789	In Stock
100 mg	$1,070	In Stock
500 mg	$2,150	In Stock
1 mL x 10 mM (in DMSO)	$239	In Stock

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Product Introduction

Bioactivity

Description	DuP-697 is an irreversible and specific inhibitor of COX-2 with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 shows antiproliferative activity with an IC50 of 42.8 nM. DuP-697 exhibits antiangiogenic, anti-inflammatory, antipyretic and apoptotic effects.
In vitro	In HT29 cells, DuP-697 (25-100 nM) causes apoptosis in a concentration-dependent manner. DuP-697 in 1, 10, and 100 nM concentrations cause antiangiogenic effects in HT29 colorectal cancer cells with antiangiogenic scores of 0.5, 0.8, and 1.2[1].
In vivo	DuP-697 inhibits bull seminal vesicle prostaglandin synthesis with an IC50 value of 24 μM and rat brain PG synthesis with an IC50 value of 4.5 μM[2].

Chemical Properties

Molecular Weight	411.31
Formula	C17H12BrFO2S2
Cas No.	88149-94-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (109.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4313 mL	12.1563 mL	24.3126 mL	121.5628 mL
5 mM	0.4863 mL	2.4313 mL	4.8625 mL	24.3126 mL
10 mM	0.2431 mL	1.2156 mL	2.4313 mL	12.1563 mL
20 mM	0.1216 mL	0.6078 mL	1.2156 mL	6.0781 mL
50 mM	0.0486 mL	0.2431 mL	0.4863 mL	2.4313 mL
100 mM	0.0243 mL	0.1216 mL	0.2431 mL	1.2156 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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