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DuP-697

🥰Excellent
Catalog No. T15181Cas No. 88149-94-4

DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values ​​of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects.

DuP-697

DuP-697

🥰Excellent
Purity: 100%
Catalog No. T15181Cas No. 88149-94-4
DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values ​​of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$106In Stock
10 mg$156In Stock
25 mg$262In Stock
50 mg$389In Stock
100 mg$572In Stock
200 mg$813In Stock
1 mL x 10 mM (in DMSO)$126In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values ​​of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects.
Targets&IC50
COX-2 (human):10 nM, COX-1 (human):800 nM
In vitro
METHODS: DuP-697 (0, 12.5, 25, 50, 100, 200 μM, 36 hours) was used to treat K562 or CML cell lines. The effects on cell growth were evaluated by MTT assay, and the effects on cell apoptosis were detected by flow cytometry.
RESULTS DuP-697 significantly inhibited the growth of K562 cells and primary CML cells with an IC50 value of 31.7 μM, and induced cell apoptosis in a concentration-dependent manner. [2]
In vivo
METHODS: DuP 697 (5 mg/kg, intraperitoneal injection) was used to treat rats 1 hour before thrombin injection to investigate its neurotoxic effects on dopaminergic neuronal degeneration in the substantia nigra (SN) of rats.
RESULTS The loss of TH-ip neurons was partially attenuated in the SN of rats treated with DuP-697. [2]
Chemical Properties
Molecular Weight411.31
FormulaC17H12BrFO2S2
Cas No.88149-94-4
SmilesCS(=O)(=O)c1ccc(cc1)-c1cc(Br)sc1-c1ccc(F)cc1
Relative Density.1.514g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (109.41 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4313 mL12.1563 mL24.3126 mL121.5628 mL
5 mM0.4863 mL2.4313 mL4.8625 mL24.3126 mL
10 mM0.2431 mL1.2156 mL2.4313 mL12.1563 mL
20 mM0.1216 mL0.6078 mL1.2156 mL6.0781 mL
50 mM0.0486 mL0.2431 mL0.4863 mL2.4313 mL
100 mM0.0243 mL0.1216 mL0.2431 mL1.2156 mL

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