Shopping Cart
- Remove All
Your shopping cart is currently empty
Edotecarin
😃Good
Catalog No. T15200Cas No. 174402-32-5
Alias PF 804950, J 107088
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Edotecarin
😃Good
Catalog No. T15200Alias PF 804950, J 107088Cas No. 174402-32-5
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | 2.156 € | 10-14 weeks | |
| 50 mg | 2.831 € | 10-14 weeks | |
| 100 mg | 3.800 € | 10-14 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Edotecarin"
Levofloxacin hydrochloride
T8747177325-13-2
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
- 35 €
Size
QTY
Norfloxacin
Cited
MK-0366
T130670458-96-7
Norfloxacin (MK-0366)(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
- 38 €
Size
QTY
CitedEtoposide Cited
VP-16-213, VP-16
T013233419-42-0
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
- 31 €
Size
QTY
CitedCiprofloxacin
Ciproxan, Ciprobay, Bay-09867, Bay o 9867
T164085721-33-1
Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.
- 38 €
Size
QTY
Berberine chloride
Natural Yellow 18, Berberine hydrochloride, Benzodioxide
T0461633-65-8
Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to parenterally but has been used orally for various fungal and parasitic infections and an anti-diarrheal.
- 27 €
Size
QTY
Ciprofloxacin monohydrochloride Cited
Ciprofloxacin hydrochloride, Ciprofloxacin HCl, Bay-09867 (hydrochloride)
T025093107-08-5
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
- 38 €
Size
QTY
CitedEIDD-1931 Cited
Beta-d-N4-hydroxycytidine
T84983258-02-4
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity that inhibits the replication of severe acute respiratory syndrome coronavirus [SARS-CoV] in Vero 76 cells, Middle East respiratory syndrome coronavirus [MERS-CoV] in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s = 0.1, 0.15, and 0.3 μM, respectively).
- 31 €
Size
QTY
CitedPrulifloxacin
Pruvel, NM441, AF 3012
T5394123447-62-1
Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II and IV.
- 38 €
Size
QTY
Enoxacin
Pd107779, NSC 629661, CI 919, AT 2266
T0717L74011-58-8
Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
- 32 €
Size
QTY
Flumequine
R-802, Flumigal
T106042835-25-6
Flumequine (R-802) is a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria. It operates by inhibiting DNA gyrase (a type II topoisomerase) and topoisomerase IV, enzymes crucial for separating bacterial DNA, thereby preventing cell division.
- 31 €
Size
QTY
Pefloxacin Mesylate
Pefloxacinium mesylate
T042570458-95-6
Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
- 31 €
Size
QTY
Irinotecan hydrochloride trihydrate
Irinotecan HCl Trihydrate, CPT-11 HCl Trihydrate
T0486136572-09-3
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.
- 34 €
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM). |
| Targets&IC50 | Topo I:50 nM, PKC:160 μM |
| In vitro | Edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner, in the presence of human colon cancer cells labeled with 3Hthymidine [1]. |
| In vivo | Edotecarin significantly delays tumor growth, achieving a delay of 10.45 days at a dosage of 3 mg/kg and extending up to 24.83 days at 100 mg/kg. It enhances survival by 83% in mice with D-456MG glioma intracranial tumors and exhibits potent antimetastatic properties [1]. Additionally, combining edotecarin with irinotecan elevates its in vivo antitumor efficacy beyond that observed with either compound individually [2]. |
| Alias | PF 804950, J 107088 |
| Molecular Weight | 608.55 |
| Formula | C29H28N4O11 |
| Cas No. | 174402-32-5 |
| Relative Density. | 1.96g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Edotecarin | purchase Edotecarin | Edotecarin cost | order Edotecarin | Edotecarin chemical structure | Edotecarin in vivo | Edotecarin in vitro | Edotecarin formula | Edotecarin molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.