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Enpp/Carbonic anhydrase-IN-1
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase, exhibiting IC50s of 1.36, 1.35, 3.00, 0.88, and 1.02 µM for NPP1, NPP2, NPP3, CA-II, and CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 also demonstrates selective antiproliferative activity for cancer cells.
Catalog No. T67775Cas No. 2883495-35-8
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Purity:100%
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Enpp/Carbonic anhydrase-IN-1
Catalog No. T67775Cas No. 2883495-35-8
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase, exhibiting IC50s of 1.36, 1.35, 3.00, 0.88, and 1.02 µM for NPP1, NPP2, NPP3, CA-II, and CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 also demonstrates selective antiproliferative activity for cancer cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $64 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $328 | In Stock | |
| 100 mg | $538 | In Stock | |
| 500 mg | $1,150 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase, exhibiting IC50s of 1.36, 1.35, 3.00, 0.88, and 1.02 µM for NPP1, NPP2, NPP3, CA-II, and CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 also demonstrates selective antiproliferative activity for cancer cells. |
| Targets&IC50 | NPP3:3 µM, CA II:0.88 µM, CA IX:1.02 µM, NPP1:1.36 µM, NPP2:1.35 µM |
| In vitro | Enpp/Carbonic anhydrase-IN-1 (0-100 µM; ) inhibits cancer cells growth with IC50s of 0.32, 0.40, 0.40, 0.58, 0.87, 0.96 µM for K-562, RPMI-8226, HT-29, SR, COLO 205, SF-539 cells, respectively. Enpp/Carbonic anhydrase-IN-1 (0-2 µM) exhibits low cytotoxic against normal skin fibroblast cells (F180) and normal breast epithelial cells (HME1) with IC50s of > 50 μM. Enpp/Carbonic anhydrase-IN-1 (0.32 µM, 0.64 µM) induces apoptosis in a dose-dependent manner at K-562 cells[1]. |
| Molecular Weight | 411.51 |
| Formula | C23H25NO4S |
| Cas No. | 2883495-35-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (218.7 mM), Sonication and heating to 50℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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