Shopping Cart
- Remove All
Your shopping cart is currently empty
ERα degrader 10
😃Good
Catalog No. T200447
ERα degrader10 is a potent, selective, orally active estrogen receptor α (ERα) degrader. It demonstrates strong ERα binding affinity (IC50 of 24.0 nM) and degradation capability (EC50 of 5.3 nM). This compound degrades ERα through a proteasome-mediated pathway and is utilized in breast cancer research.
ERα degrader 10
ERα degrader 10
😃Good
Catalog No. T200447
ERα degrader10 is a potent, selective, orally active estrogen receptor α (ERα) degrader. It demonstrates strong ERα binding affinity (IC50 of 24.0 nM) and degradation capability (EC50 of 5.3 nM). This compound degrades ERα through a proteasome-mediated pathway and is utilized in breast cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "ERα degrader 10"
Kaempferol
Cited
Robigenin, Kempferol
T2177520-18-3
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
ApoptosisAutophagyEndogenous MetaboliteEstrogen Receptor/ERREstrogen/progestogen ReceptorHIV ProteaseMitophagyParasite
- $46
Size
QTY
CitedEthisterone
Pregneninolone, 17α-Ethynyltestosterone
T0301434-03-7
Ethisterone (17α-Ethynyltestosterone) is a progestogen hormone.
- $50
Size
QTY
Tamoxifen
Cited
Z-Tamoxifen, trans-Tamoxifen, ICI47699
T690610540-29-1
Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
- $39
Size
QTY
CitedEstradiol Cited
β-Estradiol, E2, 17β-Oestradiol, 17β-Estradiol
T104850-28-2
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).
- $28
Size
QTY
CitedCholesterol Cited
Cholesteryl alcohol, Cholesterin
T076057-88-5
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
- $45
Size
QTY
CitedEstradiol benzoate Cited
Benzoestrofol, Benzhormovarine, Benovocylin
T038450-50-0
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
- $45
Size
QTY
CitedChrysin Cited
NSC 407436, 5,7-Dihydroxyflavone, 5, 7-Dihydroxyflavone
T2837480-40-0
Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.
- $42
Size
QTY
CitedEstrone
Oestrone, Fluoroethyl, Aquacrine
T100953-16-7
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
- $46
Size
QTY
Octinoxate
Octyl methoxycinnamate, Octyl 4-methoxycinnamate, ethylhexyl methoxycinnamate, 2-Ethylhexyl 4-methoxycinnamate
T00735466-77-3
Octinoxate (Octyl 4-methoxycinnamate) is used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage,primarily as an ingredient in some sunscreens and lip balms. It is also used to reduce the appearance of scars.
- $41
Size
QTY
ARV-471
Vepdegestrant
T397102229711-68-4In house
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
- $265
Size
QTY
Estriol
Oestriol, NSC-12169
T157150-27-1
Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.
- $37
Size
QTY
Genistin
Genistoside, Genistine, Genistein glucoside, Genistein 7-O-β-D-glucopyranoside, Genistein 7-glucoside
T2882529-59-9
Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities
- $60
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | ERα degrader10 is a potent, selective, orally active estrogen receptor α (ERα) degrader. It demonstrates strong ERα binding affinity (IC50 of 24.0 nM) and degradation capability (EC50 of 5.3 nM). This compound degrades ERα through a proteasome-mediated pathway and is utilized in breast cancer research. |
| Targets&IC50 | ERα:24 nM |
| In vitro | ERα degrader 10 (compound A20) exhibits potent antiproliferative effects on MCF-7 cells with an IC 50 of 0.28 nM. Demonstrating concentration-dependent degradation of ERα, the optimum degradation occurs at 24 hours using a proteasome-mediated protein degradation pathway. Moreover, ERα degrader 10 (10-100 nM; 24 h) inhibits ERα signaling and induces cell cycle arrest at the G1 phase in MCF-7 cells. |
| In vivo | ERα degrader 10 (10-30 mg/kg; oral gavage; once daily; for 30 days) demonstrated outstanding antitumor efficacy in the in vivo MCF-7 xenograft model. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy ERα degrader 10 | purchase ERα degrader 10 | ERα degrader 10 cost | order ERα degrader 10 | ERα degrader 10 in vivo | ERα degrader 10 in vitro
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.