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F-14512
😃Good
Catalog No. T27299Cas No. 866874-63-7
Alias F14512
F-14512 (free base) is a topoisomerase II inhibitor for the study of acute myeloid leukemia.
F-14512
😃Good
Catalog No. T27299Alias F14512Cas No. 866874-63-7
F-14512 (free base) is a topoisomerase II inhibitor for the study of acute myeloid leukemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | 6-8 weeks | |
| 5 mg | $722 | 6-8 weeks | |
| 10 mg | $987 | 6-8 weeks | |
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | F-14512 (free base) is a topoisomerase II inhibitor for the study of acute myeloid leukemia. |
| In vitro | The IC50 value of F-14512 in Kelly cells measured using the MTS assay was 0.076 μM, showing that F-14512 has significantly enhanced anti-tumor activity; [3] |
| In vivo | In animal experiments, F-14512 was administered to mice with neuroblastoma at a dose of 1.25 mg/kg three times a week for two consecutive weeks, showing significant and long-lasting anti-tumor effects; [3] |
| Alias | F14512 |
| Molecular Weight | 641.76 |
| Formula | C33H47N5O8 |
| Cas No. | 866874-63-7 |
| Smiles | O=C1[C@@]2([C@@H](C=3C([C@@H](NC(CNCCCNCCCCNCCCN)=O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H] |
| Relative Density. | 1.31 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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