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Daporinad hydrochloride
🥰Excellent
Catalog No. T22785Cas No. 1785666-54-7
Alias FK 866 hydrochloride (658084-64-1 free base), FK 866 hydrochloride, APO866
Daporinad hydrochloride (FK 866 hydrochloride) is a potent nicotinamide-phosphate ribosyltransferase (NAMPT) inhibitor with potential anti-tumor and anti-angiogenic activity that induces apoptosis in tumor cells.Daporinad hydrochloride can be used in the study of inflammation and cancer.
Daporinad hydrochloride
🥰Excellent
Purity: 99.18%
Catalog No. T22785Alias FK 866 hydrochloride (658084-64-1 free base), FK 866 hydrochloride, APO866Cas No. 1785666-54-7
Daporinad hydrochloride (FK 866 hydrochloride) is a potent nicotinamide-phosphate ribosyltransferase (NAMPT) inhibitor with potential anti-tumor and anti-angiogenic activity that induces apoptosis in tumor cells.Daporinad hydrochloride can be used in the study of inflammation and cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $78 | In Stock |
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Purity:99.18%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Daporinad hydrochloride (FK 866 hydrochloride) is a potent nicotinamide-phosphate ribosyltransferase (NAMPT) inhibitor with potential anti-tumor and anti-angiogenic activity that induces apoptosis in tumor cells.Daporinad hydrochloride can be used in the study of inflammation and cancer. |
| In vitro | METHODS: RPMI8226/S, U266 and MM1S cells were treated with FK866 (10nM, 24-48 hours) to study the effect of Nampt inhibitor on MAPK signaling pathway in MM cells. RESULTS: FK866 significantly reduced the gene and protein levels of pERK1/2, pp38MAPK and pSAPK/JNK, indicating that the drug has an effective inhibitory effect on MEK/ERK signaling. [1] |
| In vivo | METHODS: CB17-SCID mice injected with MM1S cells were treated with FK866 (30 mg/kg, intraperitoneal injection, twice a day, for 4 days) once a week for 3 weeks. Caliper measurements of the longest perpendicular tumor diameter were taken twice a week, and excised tumors were collected from mice for Western blot analysis to assess ERK and LC3B phosphorylation. RESULTS: A significant reduction in tumor burden was observed on day 7 of FK866 treatment, the treatment was well tolerated, without significant weight loss or neurological changes, and resulted in a significant prolongation of overall survival; tumor tissues from FK866-treated mice showed a significant reduction in ERK phosphorylation and LC3 proteolytic cleavage. [1] |
| Alias | FK 866 hydrochloride (658084-64-1 free base), FK 866 hydrochloride, APO866 |
| Molecular Weight | 427.97 |
| Formula | C24H30ClN3O2 |
| Cas No. | 1785666-54-7 |
| Smiles | Cl.O=C(C=CC=1C=NC=CC1)NCCCCC2CCN(C(=O)C=3C=CC=CC3)CC2 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (23.37 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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