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FM19G11

Catalog No. T36711   CAS 329932-55-0
Synonyms: FM19G11, HIF-1alpha/2alpha Inhibitor

FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).

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FM19G11 Chemical Structure
FM19G11, CAS 329932-55-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 43.00
5 mg In stock $ 97.00
10 mg In stock $ 178.00
25 mg In stock $ 397.00
50 mg In stock $ 589.00
100 mg In stock $ 843.00
500 mg In stock $ 1,730.00
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Purity: 97.28%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
In vitro FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxic conditions[1]. FM19G11 (300 nM) significantly enhances the pro-apoptotic effect of temozolomide, whereas FM19G11 does not induce apoptosis. In hypoxic GBM-XD, hypoxic T98G, and normoxic T98G cells, FM19G11 (300 nM) significantly inhibited the mRNA level of O6-methylguanine DNA-methyltransferase via the HIF-1α pathway[3].
In vivo Intramedullary injection of FM19G11 improves locomotion in severe spinal cord injury and induces the expression of GAP43 and RIP at the injury[2].
Synonyms FM19G11, HIF-1alpha/2alpha Inhibitor
Molecular Weight 463.4
Formula C23H17N3O8
CAS No. 329932-55-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90mg/mL (194.2mM), sonification is recommended.

TargetMolReferences and Literature

1. Moreno-Manzano et al (2010) FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J.Biol.Chem. 285 1333 2. Alastrue-Agudo et al (2018) FM19G11 and ependymal progenitor/stem cell combinatory treatment enhances neuronal preservation and oligodendrogenesis after severe spinal cord injury. Int.J.Mol.Sci. 19 E200 3. You et al (2018) FM19G11 inhibits O6-methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 7 3292

Related compound libraries

This product is contained In the following compound libraries:
Epigenetics Compound Library Bioactive Compound Library Inhibitor Library Bioactive Compounds Library Max

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Keywords

FM19G11 329932-55-0 Angiogenesis Chromatin/Epigenetic HIF HIF-1alpha/2alpha Inhibitor HIF-1a/2a Inhibitor HIF-1α/2α Inhibitor inhibitor inhibit

 

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