Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 43.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
500 mg | In stock | $ 1,730.00 |
Description | FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay). |
In vitro | FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxic conditions[1]. FM19G11 (300 nM) significantly enhances the pro-apoptotic effect of temozolomide, whereas FM19G11 does not induce apoptosis. In hypoxic GBM-XD, hypoxic T98G, and normoxic T98G cells, FM19G11 (300 nM) significantly inhibited the mRNA level of O6-methylguanine DNA-methyltransferase via the HIF-1α pathway[3]. |
In vivo | Intramedullary injection of FM19G11 improves locomotion in severe spinal cord injury and induces the expression of GAP43 and RIP at the injury[2]. |
Synonyms | FM19G11, HIF-1alpha/2alpha Inhibitor |
Molecular Weight | 463.4 |
Formula | C23H17N3O8 |
CAS No. | 329932-55-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90mg/mL (194.2mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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FM19G11 329932-55-0 Angiogenesis Chromatin/Epigenetic HIF HIF-1alpha/2alpha Inhibitor HIF-1a/2a Inhibitor HIF-1α/2α Inhibitor inhibitor inhibit