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FTBMT

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Purity:99.12%

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COA HNMR HPLC

FTBMT

Catalog No. T15352Cas No. 1358575-02-6

FTBMT is a selective GPR52 agonist (EC50: 75 nM) and it also has antipsychotic and procognitive properties.

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Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$86	In Stock
10 mg	$148	In Stock
25 mg	$329	In Stock
50 mg	$581	In Stock
100 mg	$829	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock

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Product Introduction

Bioactivity

Description	FTBMT is a selective GPR52 agonist (EC50: 75 nM) and has antipsychotic and procognitive properties.
Targets&IC50	GPR52:75 nM(EC50)
In vitro	In CHO cells expressing human, mouse, or rat GPR52, FTBMT (0.1-10 μM) improves intracellular cAMP levels (pEC50s of 7.03, 6.85, and 6.87, respectively)[2].
In vivo	In rats, FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory. FTBMT (30 mg/kg, 90 minutes) shows antipsychotic-like activity without causing catalepsy in mice[2]

Chemical Properties

Molecular Weight	392.35
Formula	C19H16F4N4O
Cas No.	1358575-02-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (114.69 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5487 mL	12.7437 mL	25.4874 mL	127.4372 mL
5 mM	0.5097 mL	2.5487 mL	5.0975 mL	25.4874 mL
10 mM	0.2549 mL	1.2744 mL	2.5487 mL	12.7437 mL
20 mM	0.1274 mL	0.6372 mL	1.2744 mL	6.3719 mL
50 mM	0.0510 mL	0.2549 mL	0.5097 mL	2.5487 mL
100 mM	0.0255 mL	0.1274 mL	0.2549 mL	1.2744 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc