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Glafenine Hydrochloride

🥰Excellent
Catalog No. T0055LCas No. 65513-72-6
Alias Glafenin hydrochloride

Glafenine Hydrochloride is an anti-inflammatory agent.

Glafenine Hydrochloride

Glafenine Hydrochloride

🥰Excellent
Purity: 98.91%
Catalog No. T0055LAlias Glafenin hydrochlorideCas No. 65513-72-6
Glafenine Hydrochloride is an anti-inflammatory agent.
Pack SizePriceAvailabilityQuantity
50 mg$33In Stock
100 mg$48In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Purity:98.91%
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Product Introduction

Bioactivity
Description
Glafenine Hydrochloride is an anti-inflammatory agent.
Targets&IC50
ABCG2:3.2 μM
In vitro
Glafenine enhances the surface expression of mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in baby hamster kidney (BHK) cells, achieving 40% of the expression levels seen in wild-type CFTR[2]. Additionally, Glafenine hydrochloride suppresses the proliferation and clonogenic capabilities of human aortic smooth muscle cells (haSMCs) and endothelial cells (ECs) in a dose-responsive manner, leading to a blockade at the G2/M phase of the cell cycle and a decline in the G1 phase. Moreover, it dose-dependently impairs the migratory capacity of haSMCs and decreases the level of the extracellular matrix protein tenascin[3].
Cell Research
Glafenine hydrochloride is added to the culture medium of the smooth muscle cells at three concentrations (10 μM, 50 μM, 100 μM). After 4 days of treatment, cells are harvested and the absolute cell number is counted[3].
AliasGlafenin hydrochloride
Chemical Properties
Molecular Weight409.26
FormulaC19H17ClN2O4·HCl
Cas No.65513-72-6
SmilesCl.OCC(O)COC(=O)c1ccccc1Nc1ccnc2cc(Cl)ccc12
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL

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