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Glafenine Hydrochloride is an anti-inflammatory agent.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $33 | In Stock | |
100 mg | $48 | In Stock | |
1 mL x 10 mM (in DMSO) | $54 | In Stock |
Description | Glafenine Hydrochloride is an anti-inflammatory agent. |
Targets&IC50 | ABCG2:3.2 μM |
In vitro | Glafenine enhances the surface expression of mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in baby hamster kidney (BHK) cells, achieving 40% of the expression levels seen in wild-type CFTR[2]. Additionally, Glafenine hydrochloride suppresses the proliferation and clonogenic capabilities of human aortic smooth muscle cells (haSMCs) and endothelial cells (ECs) in a dose-responsive manner, leading to a blockade at the G2/M phase of the cell cycle and a decline in the G1 phase. Moreover, it dose-dependently impairs the migratory capacity of haSMCs and decreases the level of the extracellular matrix protein tenascin[3]. |
Cell Research | Glafenine hydrochloride is added to the culture medium of the smooth muscle cells at three concentrations (10 μM, 50 μM, 100 μM). After 4 days of treatment, cells are harvested and the absolute cell number is counted[3]. |
Alias | Glafenin hydrochloride |
Molecular Weight | 409.26 |
Formula | C19H17ClN2O4·HCl |
Cas No. | 65513-72-6 |
Smiles | Cl.OCC(O)COC(=O)c1ccccc1Nc1ccnc2cc(Cl)ccc12 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 60 mg/mL |
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