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GLL 398

Catalog No. T9997Cas No. 2077980-80-2

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.

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Pack Size	Price	Availability
1 mg	$195	Backorder
5 mg	$437	Backorder
10 mg	$655	Backorder
25 mg	$1,178	Backorder
50 mg	$1,768	Backorder
100 mg	$2,652	Backorder
200 mg	$3,978	Backorder
1 mL x 10 mM (in DMSO)	$447	Backorder

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Product Introduction

Bioactivity

Description	GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
In vitro	GLL398 exhibits a strong dose-dependent binding profile for the estrogen receptor with a Y537S point mutation with an IC50 of 29.5 nM[1].

Chemical Properties

Molecular Weight	398.26
Formula	C25H23BO4
Cas No.	2077980-80-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 245 mg/mL (615.18 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5109 mL	12.5546 mL	25.1092 mL	125.5461 mL
5 mM	0.5022 mL	2.5109 mL	5.0218 mL	25.1092 mL
10 mM	0.2511 mL	1.2555 mL	2.5109 mL	12.5546 mL
20 mM	0.1255 mL	0.6277 mL	1.2555 mL	6.2773 mL
50 mM	0.0502 mL	0.2511 mL	0.5022 mL	2.5109 mL
100 mM	0.0251 mL	0.1255 mL	0.2511 mL	1.2555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc