Shopping Cart
- Remove All
Your shopping cart is currently empty
Golimumab
🥰Excellent
Catalog No. T76711Cas No. 476181-74-5
Alias SCH 900259, MK-8259, CNTO-148
Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anticancer activity. It inhibits the production of IL-6 and IL-1β, induces apoptosis, and can be used to prevent inflammation and destruction of cartilage or bone. This makes Golimumab valuable for studying rheumatoid arthritis and cancer.
Golimumab
🥰Excellent
Purity: 99.7% (SEC-HPLC)
Catalog No. T76711Alias SCH 900259, MK-8259, CNTO-148Cas No. 476181-74-5
Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anticancer activity. It inhibits the production of IL-6 and IL-1β, induces apoptosis, and can be used to prevent inflammation and destruction of cartilage or bone. This makes Golimumab valuable for studying rheumatoid arthritis and cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $243 | In Stock | |
| 5 mg | $562 | In Stock | |
| 10 mg | $783 | In Stock | |
| 25 mg | $1,190 | In Stock | |
| 50 mg | $1,590 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Golimumab"
Acetylcysteine
Cited
N-Acetyl-L-cysteine, N-Acetylcysteine, N-Acetyl Cysteine, NAC, LNAC
T0875616-91-1
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.
- $33
Size
QTY
CitedGlucosamine Cited
D-Glucosamine, Chitosamine
T04293416-24-8
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
- $50
Size
QTY
CitedApremilast
CC-10004
T2923608141-41-9
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
- $43
Size
QTY
Lenalidomide Cited
CC-5013
T1642191732-72-6
Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.
- $36
Size
QTY
CitedFisetin Cited
T2879528-48-3
Fisetin belongs to a group of natural flavonols with a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects.
- $41
Size
QTY
CitedLinalool
Phantol, Linalol, (±)-Linalool
T2S226478-70-6
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury through induction of antioxidant defense via Nrf2 activating and reduction inflammatory response via NF-κB inhibition. 3. Linalool biosynthesis and accumulation might be involved in plant defense against bacterial and fungal pathogens and be associated with field resistance to citrus canker. 4. Linalool significantly increased the expression of antioxidant enzymes regulated by Nrf-2 and diminished lung tissue levels of several pro-inflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (IL)-6.
- $29
Size
QTY
Acefylline
Theophyllineacetic acid, Theophylline-7-acetic acid, Carboxymethyltheophylline, acetyloxytheophylline
T2205652-37-9
Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help offset its stimulant effects
- $33
Size
QTY
Thalidomide Cited
Thalomid, Sedoval
T021350-35-1
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
- $50
Size
QTY
CitedPomalidomide Cited
CC-4047
T238419171-19-8
Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN) and is commonly used in the synthesis of PROTAC products.
- $52
Size
QTY
CitedTaxifolin Cited
Dihydroquercetin, (+)-Taxifolin, (+)-Dihydroquercetin
T1738480-18-2
Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
- $30
Size
QTY
CitedTaurochenodeoxycholic Acid Cited
TCDCA, Taurochenodeoxycholate, Chenyltaurine, Chenodeoxycholyltaurine, 12-Deoxycholyltaurine
T2A2481516-35-8
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
- $39
Size
QTY
CitedBergenin Cited
Cuscutin, Bengenin
T0122477-90-7
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
- $50
Size
QTY
CitedSelect Batch
Concentration:2.37 mg/mL
Purity:99.7% (SEC-HPLC)
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anticancer activity. It inhibits the production of IL-6 and IL-1β, induces apoptosis, and can be used to prevent inflammation and destruction of cartilage or bone. This makes Golimumab valuable for studying rheumatoid arthritis and cancer. |
| In vitro | Inducing reductions in the viability of transmembrane TNFα–expressing cells, Golimumab (CNTO-148) (0.1-10 μg/mL; 24-72 hours; transmembrane TNFα–transfected Jurkat cells) [1].Inducing apoptosis, increasing the levels of active caspase-3, and inducing apoptotic DNA fragmentation, Golimumab (CNTO-148) (10 μg/mL; 48 hours; transmembrane TNFα–transfected Jurkat cells) [1]. |
| In vivo | Golimumab (CNTO-148), administered intraperitoneally at doses of 1-10 mg/kg daily for 4 weeks in the Tg197 transgenic mouse model, relieves TNFα-induced arthritis in a mouse model of humans [3].Golimumab (CNTO-148), administered intravenously at a dose of 24 mg/kg daily for 7 days in Swiss-albino healthy male mice, inhibits oxidative stress, apoptotic cell death, and inflammatory response, thereby improving renal function. Golimumab reduces all markers of kidney injury and attenuates cell death [3]. |
| Alias | SCH 900259, MK-8259, CNTO-148 |
| Molecular Weight | 146.93 kDa |
| Cas No. | 476181-74-5 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Golimumab | purchase Golimumab | Golimumab cost | order Golimumab | Golimumab chemical structure | Golimumab in vivo | Golimumab in vitro | Golimumab molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.