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GPR120 Agonist 3

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COA HNMR HPLC

GPR120 Agonist 3

Catalog No. T15413Cas No. 1599477-75-4

GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62).

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Pack Size	Price	Availability
1 mg	$35	In Stock
2 mg	$50	In Stock
5 mg	$81	In Stock
10 mg	$147	In Stock
25 mg	$289	In Stock
50 mg	$413	In Stock
100 mg	$619	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Product Introduction

Bioactivity

Description	GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62).
In vitro	GPR120-IN-1 causes a concentration-dependent response to recruiting β-arrestin-2 in both human and mouse Gpr120 expressing cells(EC50s: ~0.35 μM). GPR120-IN-1 produces concentration-dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Ikkβ, Tak1, and Jnk and blocked IκB degradation.
In vivo	GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism. It causes decreased liver triglycerides, decreased hepatic steatosis, and DAGs, as well as decreased saturated free fatty acid content. GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates. It also enhanced the insulin stimulated-glucose disposal rate. Only in WT mice, along with a marked increase in the ability of insulin to suppress hepatic glucose production.
Alias	GPR120-IN-1

Chemical Properties

Molecular Weight	405.84
Formula	C19H23ClF3NO3
Cas No.	1599477-75-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (123.20 mM)

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4640 mL	12.3201 mL	24.6403 mL	123.2013 mL
5 mM	0.4928 mL	2.4640 mL	4.9281 mL	24.6403 mL
10 mM	0.2464 mL	1.2320 mL	2.4640 mL	12.3201 mL
20 mM	0.1232 mL	0.6160 mL	1.2320 mL	6.1601 mL
50 mM	0.0493 mL	0.2464 mL	0.4928 mL	2.4640 mL
100 mM	0.0246 mL	0.1232 mL	0.2464 mL	1.2320 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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