Shopping Cart
- Remove All
Your shopping cart is currently empty
GPX4-IN-4
😃Good
Catalog No. T74846Cas No. 2920221-53-8
GPX4-IN-4 (Compound 24) is a potent inhibitor of GPX4, employed in cancer research [1].
GPX4-IN-4
GPX4-IN-4
😃Good
Catalog No. T74846Cas No. 2920221-53-8
GPX4-IN-4 (Compound 24) is a potent inhibitor of GPX4, employed in cancer research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 8-10 weeks | |
| 50 mg | $2,180 | 8-10 weeks | |
| 100 mg | $2,800 | 8-10 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "GPX4-IN-4"
Melatonin
Cited
N-Acetyl-5-methoxytryptamine, Melatonine
T165973-31-4
Melatonin (Melatonine) is a natural hormone secreted by the pineal gland that activates melatonin receptors. Melatonin is a hormone that regulates the biological clock and also has antioxidant and anti-inflammatory activities.
ApoptosisAutophagyCaMKEndogenous MetaboliteEstrogen/progestogen ReceptorGlutathione PeroxidaseMelatonin ReceptorMitophagyROR
- $31
Size
QTY
Cited5-Aminosalicylic Acid
Cited
Mesalazine, Mesalamine, 5-ASA
T064689-57-6
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
- $45
Size
QTY
CitedRSL3 Cited
RSL3 1S, 1S,3R-RSL3
T36461219810-16-8
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.
- $33
Size
QTY
CitedNabumetone
BRL14777
T125842924-53-8
Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
- $45
Size
QTY
PF-1355
ZINC205721785, PF-06281355, PF 06281355
T35111435467-38-1
PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
- $30
Size
QTY
4-POBN
NSC-640, NSC640, NSC 640, Myeloperoxidase Inhibitor 1, 4-Aminobenzohydrazide, 4-ABAH
T263895351-17-7
4-POBN (Myeloperoxidase Inhibitor 1) is a potent and irreversible inhibitor of myeloperoxidase (IC50 = 0.3 µM). 4-POBN can be used in studies about subacute stroke.
- $34
Size
QTY
ML162 Cited
T89701035072-16-2
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity and selectively inhibits cell lines expressing mutant RAS oncogenes.
- $91
Size
QTY
Cited4-Methylesculetin
Methylesculetin, 4-Methyl-6,7-dihydroxycoumarin
TJS0338529-84-0
4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
- $30
Size
QTY
AZD8309
AZD-8309, AZD 8309
T25131333742-48-6In house
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the pancreas.AZD8309 can be used to study a range of inflammatory diseases.
- $129
Size
QTY
GSTO1-IN-1
T11505568544-03-6
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1) with an IC50 of 31 nM.
- $34
Size
QTY
Cefdinir
PD 134393, FK-482, CI-983
T013391832-40-5
Cefdinir (FK-482) is a third-generation, semi-synthetic cephalosporin antibiotic effective against common bacterial infections of the ear, sinus, throat, and skin.
- $54
Size
QTY
ML-210 Cited
CID 49766530
T83751360705-96-9
ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis.
- $34
Size
QTY
CitedContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | GPX4-IN-4 (Compound 24) is a potent inhibitor of GPX4, employed in cancer research [1]. |
| In vitro | GPX4-IN-4 (Compound 24) reduces HT1080 cell viability in a dose- and time-dependent fashion at concentrations ranging from 0 to 1000 nM and durations up to 24 hours [1]. Similarly, GPX4-IN-4 demonstrates inhibitory effects on NCI-H1703 cell viability over 72 hours, with EC50 values of 0.117 μM without Fer-1 and 4.74 μM with Fer-1 [1]. |
| In vivo | GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) targets renal GPX4 and induces the expression of PD biomarkers in mice [1]. Despite partial target engagement observed in tumor masses, GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) does not affect the growth of WSU-DLCL2 tumors in mice [1]. |
| Molecular Weight | 460.93 |
| Formula | C22H21ClN2O5S |
| Cas No. | 2920221-53-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy GPX4-IN-4 | purchase GPX4-IN-4 | GPX4-IN-4 cost | order GPX4-IN-4 | GPX4-IN-4 in vivo | GPX4-IN-4 in vitro | GPX4-IN-4 formula | GPX4-IN-4 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.