Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

GS-9667

🥰Excellent
Catalog No. T27439Cas No. 618380-90-8
Alias CVT-3619, CVT 3619

GS-9667, a selective and partial agonist of the A(1) adenosine receptor (AR), represents an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).

GS-9667

GS-9667

🥰Excellent
Purity: 99.76%
Catalog No. T27439Alias CVT-3619, CVT 3619Cas No. 618380-90-8
GS-9667, a selective and partial agonist of the A(1) adenosine receptor (AR), represents an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).
Pack SizePriceAvailabilityQuantity
1 mg$113In Stock
5 mg$289In Stock
10 mg$396In Stock
25 mg$653In Stock
50 mg$892In Stock
100 mg$1,230In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "GS-9667"

Select Batch
Purity:99.76%
ee:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
GS-9667, a selective and partial agonist of the A(1) adenosine receptor (AR), represents an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).
In vivo
In the single ascending dose study, healthy, non-obese, and obese subjects received GS-9667 (30-1,800 mg; oral; single dose). In the multiple, ascending dose study, healthy, obese subjects received GS-9667 (600-2,400 mg QD, 1,200 mg BID, or 600 mg QID) for 14 days. Doses of GS-9667 ≥300 mg caused dose-dependent reductions in FFA levels that were reproducible over 14 days without evidence of desensitization or rebound. All doses were well tolerated. GS-9667 was rapidly absorbed and distributed; Steady-state concentrations were achieved within 3-5 days. The A(1) AR partial agonist GS-9667 reduced plasma FFA, exhibited linear kinetics, and was well-tolerated in healthy non-obese and obese subjects.[1]
AliasCVT-3619, CVT 3619
Chemical Properties
Molecular Weight461.51
FormulaC21H24FN5O4S
Cas No.618380-90-8
SmilesO[C@H]1[C@H](N2C=3C(N=C2)=C(N[C@H]4[C@H](O)CCC4)N=CN3)O[C@H](CSC5=C(F)C=CC=C5)[C@H]1O
Relative Density.1.68 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (119.17 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1668 mL10.8340 mL21.6680 mL108.3400 mL
5 mM0.4334 mL2.1668 mL4.3336 mL21.6680 mL
10 mM0.2167 mL1.0834 mL2.1668 mL10.8340 mL
20 mM0.1083 mL0.5417 mL1.0834 mL5.4170 mL
50 mM0.0433 mL0.2167 mL0.4334 mL2.1668 mL
100 mM0.0217 mL0.1083 mL0.2167 mL1.0834 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy GS-9667 | purchase GS-9667 | GS-9667 cost | order GS-9667 | GS-9667 chemical structure | GS-9667 in vivo | GS-9667 formula | GS-9667 molecular weight