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HC-070

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Purity:97.06%

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COA HPLC HNMR

HC-070

Catalog No. T15465Cas No. 1628291-95-1

HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).

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Pack Size	Price	Availability
1 mg	$135	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,060	In Stock
100 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$295	In Stock

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Product Introduction

Bioactivity

Description	HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).
Targets&IC50	TRPC5 (human):9.3 nM, TRPC4 (human):46 nM
In vitro	HC-070 inhibits hTRPC5 currents activated via muscarinic type 1 (IC50 = 2.0 nM) and suppresses hTRPC4 currents via muscarinic type 2 (IC50 = 0.49 nM). In whole-cell manual patch clamp, HC-070 inhibits lanthanum-activated hTRPC5-, mTRPC5-, rTRPC5-mediated currents (IC50s of 0.52 nM, 0.55 nM, and 0.32 nM). In the amygdala slices, HC-070 (20 nM) decreases CCK-4-evoked neuronal activity. HC-070 weakly inhibits TRPC3 (IC50 = 1 μM) and blocks M2R-activated human TRPC1/TRPC4 channels (IC50 = 1.3 nM) and La3+- and M1R-activated human TRPC1/5 channels (IC50 = 1.4 nM and 4.4 nM)[1].
In vivo	HC-070 (1 mg/kg) reduces the increased capacity for fear memory in mice subjected to chronic social stress on days 1-15. HC-070 (1 mg/kg, p.o.) affects mice with increased CCK-4-evoked anxiety. HC-070 (0.3-3 mg/kg, p.o.) causes a reduction of anxiety in a standard EPM. HC-070 (0.3-10 mg/kg, p.o.) reduces the time of immobility in a tail suspension test without impacting locomotor activity in mice. HC-070 (1-10 mg/kg, p.o.) reduces marble-burying behavior[1].
Alias	HC 070

Chemical Properties

Molecular Weight	475.32
Formula	C22H20Cl2N4O4
Cas No.	1628291-95-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (105.2 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1038 mL	10.5192 mL	21.0385 mL	105.1923 mL
5 mM	0.4208 mL	2.1038 mL	4.2077 mL	21.0385 mL
10 mM	0.2104 mL	1.0519 mL	2.1038 mL	10.5192 mL
20 mM	0.1052 mL	0.5260 mL	1.0519 mL	5.2596 mL
50 mM	0.0421 mL	0.2104 mL	0.4208 mL	2.1038 mL
100 mM	0.0210 mL	0.1052 mL	0.2104 mL	1.0519 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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