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Hesperetin 7-O-glucoside

🥰Excellent
Catalog No. TN1733Cas No. 31712-49-9

Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers.

Hesperetin 7-O-glucoside

Hesperetin 7-O-glucoside

🥰Excellent
Purity: 98.1%
Catalog No. TN1733Cas No. 31712-49-9
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers.
Pack SizePriceAvailabilityQuantity
1 mg$64In Stock
5 mg$163In Stock
10 mg$263In Stock
25 mg$472In Stock
50 mg$689In Stock
100 mg$1,080In Stock
200 mg$1,450In Stock
1 mL x 10 mM (in DMSO)$193In Stock
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Purity:98.1%
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Product Introduction

Bioactivity
Description
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers.
In vitro
Hesperetin 7-O-glucoside (Hes-7-G) was produced by the enzymatic conversion of hesperidin by Aspergillus sojae naringinase due to the removal of the terminal rhamnose.Extracts from orange juice and peel containing the hesperidin were so treated by this enzyme that the hesperidin could also be converted to Hesperetin 7-O-glucoside . The solubility of Hesperetin 7-O-glucoside in 10% ethanol was enhanced 55- and 88-fold over those of hesperidin and hesperetin, respectively, which may make Hesperetin 7-O-glucoside more bioavailable. Hesperetin 7-O-glucoside was 1.7- and 2.4-fold better than hesperidin and hesperetin, respectively, in the inhibition of human intestinal maltase. Hesperetin 7-O-glucoside was more potent by 2- and 4-fold than hesperidin in the inhibition of human HMG-CoA reductase. Additionally, Hesperetin 7-O-glucoside exhibited more effective inhibition of the growth of Helicobacter pylori than hesperetin, while its effectiveness was similar to that of hesperidin.
Chemical Properties
Molecular Weight464.42
FormulaC22H24O11
Cas No.31712-49-9
SmilesCOc1ccc(cc1O)[C@@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc2O1
Relative Density.1.569 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (59.21 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1532 mL10.7661 mL21.5322 mL107.6612 mL
5 mM0.4306 mL2.1532 mL4.3064 mL21.5322 mL
10 mM0.2153 mL1.0766 mL2.1532 mL10.7661 mL
20 mM0.1077 mL0.5383 mL1.0766 mL5.3831 mL
50 mM0.0431 mL0.2153 mL0.4306 mL2.1532 mL

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