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HX 531

🥰Excellent
Catalog No. T22843Cas No. 188844-34-0

HX 531 is a RXR antagonist (IC50 of 18 nM). HX 531 prevents HF diet-induced obesity, insulin resistance, and diabetes by reducing tissue TG content in white adipose tissue (WAT), skeletal muscle, and liver in mice.

HX 531

HX 531

🥰Excellent
Purity: 99.43%
Catalog No. T22843Cas No. 188844-34-0
HX 531 is a RXR antagonist (IC50 of 18 nM). HX 531 prevents HF diet-induced obesity, insulin resistance, and diabetes by reducing tissue TG content in white adipose tissue (WAT), skeletal muscle, and liver in mice.
Pack SizePriceAvailabilityQuantity
1 mg$39 In Stock
5 mg$68 In Stock
10 mg$122 In Stock
25 mg$271 In Stock
50 mgInquiryIn Stock
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Purity:99.43%
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Product Introduction

Bioactivity
Description
HX 531 is a RXR antagonist (IC50 of 18 nM). HX 531 prevents HF diet-induced obesity, insulin resistance, and diabetes by reducing tissue TG content in white adipose tissue (WAT), skeletal muscle, and liver in mice.
Targets&IC50
RXR:18 nM
In vivo
METHODS: HX531 (100 mg/kg, oral) was administered to mice, and the maximum plasma concentration (Cmax), time required to reach maximum concentration (Tmax), area under the plasma concentration-time curve (AUC), and elimination half-life (t1/2) were measured by HPLC and gas chromatography.
RESULTS In mice, they were 4.1 μg/mL, 1.5 hours, 19.3 μg h/mL, and 1.9 hours, respectively. [2]
Chemical Properties
Molecular Weight483.56
FormulaC29H29N3O4
Cas No.188844-34-0
SmilesCN1c2ccc(cc2N=C(c2ccc(cc2)C(O)=O)c2cc3c(cc12)C(C)(C)CCC3(C)C)[N+]([O-])=O
Relative Density.1.27 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3 mg/mL (6.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0680 mL10.3400 mL20.6800 mL103.3998 mL
5 mM0.4136 mL2.0680 mL4.1360 mL20.6800 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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