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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $55 | In Stock | |
10 mg | $73 | In Stock | |
25 mg | $113 | In Stock | |
50 mg | $161 | In Stock | |
1 mL x 10 mM (in DMSO) | $59 | In Stock |
Description | INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively. |
In vitro | INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM[1]. |
In vivo | In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently[1]. |
Alias | 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one |
Molecular Weight | 235.3 |
Formula | C12H13NO2S |
Cas No. | 1169755-45-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (21.25 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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