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JNJ-1013
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Catalog No. T78054Cas No. 2597343-08-1
JNJ-1013 is a potent and selective IRAK1 degrader, with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases cleaved PARP expression, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705) [1].
JNJ-1013
😃Good
Catalog No. T78054Cas No. 2597343-08-1
JNJ-1013 is a potent and selective IRAK1 degrader, with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases cleaved PARP expression, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705) [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $673 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-1013 is a potent and selective IRAK1 degrader, with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases cleaved PARP expression, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705) [1]. |
| Targets&IC50 | IRAK4:443 nM, VHL FP:1071 nM, IRAK1:72 nM |
| In vitro | JNJ-1013 (Degrader-3; 1.5-10000 nM; 24 hours) degrades IRAK1 protein in a dose-dependent manner with a DC50 value of 3 nM [1]. At 1 µM, JNJ-1013 diminishes the expression of IRAK1 induced by MG-132 in a dose-dependent fashion [1]. Additionally, JNJ-1013 (0.01, 0.03, 0.1, 0.3, 1 µM; 24 h) reduces the expression of IRAK1, p-IKBα, pSTAT3(Tyr705), and increases the expression of cleaved PARP [1]. |
| Molecular Weight | 878.05 |
| Formula | C46H55N9O7S |
| Cas No. | 2597343-08-1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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