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Juglone

🥰Excellent
Catalog No. T4010Cas No. 481-39-0
Alias Regianin, 5-Hydroxy-1,4-naphthoquinone

Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

Juglone

Juglone

🥰Excellent
Purity: 98.73%
Catalog No. T4010Alias Regianin, 5-Hydroxy-1,4-naphthoquinoneCas No. 481-39-0
Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
Pack SizePriceAvailabilityQuantity
5 mg$41In Stock
10 mg$56In Stock
25 mg$96In Stock
50 mg$135In Stock
100 mg$189In Stock
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Purity:98.73%
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Product Introduction

Bioactivity
Description
Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
AliasRegianin, 5-Hydroxy-1,4-naphthoquinone
Chemical Properties
Molecular Weight174.15
FormulaC10H6O3
Cas No.481-39-0
SmilesOc1cccc2C(=O)C=CC(=O)c12
Relative Density.1.2346 g/cm3 (Estimated)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice.
Solubility Information
DMSO: 5.56 mg/mL (31.9 mM), The compound is unstable in solution. Please use soon.(DMSO inactivates the activity of Juglone.)
Ethanol: 15 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.7422 mL28.7109 mL57.4218 mL287.1088 mL
5 mM1.1484 mL5.7422 mL11.4844 mL57.4218 mL
10 mM0.5742 mL2.8711 mL5.7422 mL28.7109 mL
20 mM0.2871 mL1.4355 mL2.8711 mL14.3554 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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