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KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants. |
Targets&IC50 | KRas G12C:0.019 nM (Kd), KRas G12D:0.019 nM (Kd), KRas G12V:0.096 nM (Kd) |
In vitro | KRAS inhibitor-31 (compound 33) exhibits potent inhibitory activity, with IC50 values measured at 1.1 nM in Panc08.13 cells, 3.9 nM in H358 cells, and 6.6 nM in SW620 cells. |
Molecular Weight | 617.62 |
Formula | C33H30F3N5O4 |
Cas No. | 2920695-77-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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