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KSI-3716

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Catalog No. T11783Cas No. 1151813-61-4
Alias KSI3716

KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research.

KSI-3716

KSI-3716

😃Good
Purity: 98.94%
Catalog No. T11783Alias KSI3716Cas No. 1151813-61-4
KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research.
Pack SizePriceAvailabilityQuantity
2 mg$242In Stock
5 mg$2975 days
25 mg$9876-8 weeks
50 mg$1,3606-8 weeks
100 mg$1,8606-8 weeks
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Purity:98.94%
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Product Introduction

Bioactivity
Description
KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research.
Targets&IC50
c-Myc:0.86 μM
In vitro
KSI-3716 is a potent c-Myc inhibitor that blocks the binding of c-MYC/MAX to target gene promoters. KSI-3716 is used as an intravesical chemotherapy agent. KSI-3716 effectively blocks complex formation in a dose-dependent manner, IC50 0.86 μM. C-myc-mediated transcription activity was inhibited by KSI-3716 at concentrations as low as 1 μM. KSI-3716 has cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis. [1]
In vivo
KSI-3716 was injected into the bladder of mice xenografted with bladder cancer at a dose of 5 mg/kg, and it was observed that it could significantly inhibit tumor growth and had little systemic toxicity. [1]
AliasKSI3716
Chemical Properties
Molecular Weight426.09
FormulaC17H11BrCl2N2O2
Cas No.1151813-61-4
SmilesO=C1C=2C(Cl)=CC=C(Br)C2NC(NC3=CC=C(Cl)C=C3)=C1C(=O)C
Relative Density.1.675 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 2 mg/mL (4.69 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3469 mL11.7346 mL23.4692 mL117.3461 mL

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