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KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $242 | In Stock | |
5 mg | $297 | 5 days | |
25 mg | $987 | 6-8 weeks | |
50 mg | $1,360 | 6-8 weeks | |
100 mg | $1,860 | 6-8 weeks |
Description | KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research. |
Targets&IC50 | c-Myc:0.86 μM |
In vitro | KSI-3716 is a potent c-Myc inhibitor that blocks the binding of c-MYC/MAX to target gene promoters. KSI-3716 is used as an intravesical chemotherapy agent. KSI-3716 effectively blocks complex formation in a dose-dependent manner, IC50 0.86 μM. C-myc-mediated transcription activity was inhibited by KSI-3716 at concentrations as low as 1 μM. KSI-3716 has cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis. [1] |
In vivo | KSI-3716 was injected into the bladder of mice xenografted with bladder cancer at a dose of 5 mg/kg, and it was observed that it could significantly inhibit tumor growth and had little systemic toxicity. [1] |
Alias | KSI3716 |
Molecular Weight | 426.09 |
Formula | C17H11BrCl2N2O2 |
Cas No. | 1151813-61-4 |
Smiles | O=C1C=2C(Cl)=CC=C(Br)C2NC(NC3=CC=C(Cl)C=C3)=C1C(=O)C |
Relative Density. | 1.675 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
Solubility Information | DMSO: 2 mg/mL (4.69 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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