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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $242 | 5 days | |
5 mg | $297 | 5 days | |
25 mg | $987 | 6-8 weeks | |
50 mg | $1,360 | 6-8 weeks | |
100 mg | $1,860 | 6-8 weeks |
Description | KSI-3716 is an inhibitor of c-Myc. |
In vitro | KSI-3716 effectively blocks complex formation in a dose dependent manner (IC50=0.84 μM).?c-MYC mediated transcriptional activity is inhibited by KSI-3716 at concentrations as low as 1 μM.?The expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, is markedly decreased.?KSI-3716 exerts cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.KSI-3716 blocks c-MYC/MAX from forming a complex with target gene promoters. |
In vivo | Perfusion of KSI-3716 through the bladder at a dose of 5 mg/kg can significantly inhibit tumor growth with minimal systemic toxicity. |
Molecular Weight | 426.09 |
Formula | C17H11BrCl2N2O2 |
Cas No. | 1151813-61-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (11.73 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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