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KSI-3716
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Catalog No. T11783Cas No. 1151813-61-4
Alias KSI3716
KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research.
KSI-3716
😃Good
Purity: 98.94%
Catalog No. T11783Alias KSI3716Cas No. 1151813-61-4
KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $242 | In Stock | |
| 5 mg | $297 | 5 days | |
| 25 mg | $987 | 6-8 weeks | |
| 50 mg | $1,360 | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks |
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Purity:98.94%
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Product Introduction
Bioactivity
Chemical Properties
| Description | KSI-3716 is a c-Myc inhibitor used as a bladder chemotherapy agent. It blocks the formation of the c-MYC/MAX complex with the target gene promoter and induces cell cycle arrest and apoptosis. It can be used for bladder cancer research. |
| Targets&IC50 | c-Myc:0.86 μM |
| In vitro | KSI-3716 is a potent c-Myc inhibitor that blocks the binding of c-MYC/MAX to target gene promoters. KSI-3716 is used as an intravesical chemotherapy agent. KSI-3716 effectively blocks complex formation in a dose-dependent manner, IC50 0.86 μM. C-myc-mediated transcription activity was inhibited by KSI-3716 at concentrations as low as 1 μM. KSI-3716 has cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis. [1] |
| In vivo | KSI-3716 was injected into the bladder of mice xenografted with bladder cancer at a dose of 5 mg/kg, and it was observed that it could significantly inhibit tumor growth and had little systemic toxicity. [1] |
| Alias | KSI3716 |
| Molecular Weight | 426.09 |
| Formula | C17H11BrCl2N2O2 |
| Cas No. | 1151813-61-4 |
| Smiles | O=C1C=2C(Cl)=CC=C(Br)C2NC(NC3=CC=C(Cl)C=C3)=C1C(=O)C |
| Relative Density. | 1.675 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 2 mg/mL (4.69 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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