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L-798106
🥰Excellent
Catalog No. T15689Cas No. 244101-02-8
Alias L 798106, GW-671021, GW671021, CM-9, CM9
L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough.
L-798106
🥰Excellent
Purity: 98.97%
Catalog No. T15689Alias L 798106, GW-671021, GW671021, CM-9, CM9Cas No. 244101-02-8
L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $106 | In Stock | |
| 10 mg | $168 | In Stock | |
| 25 mg | $347 | In Stock | |
| 50 mg | $558 | In Stock | |
| 100 mg | $893 | In Stock | |
| 200 mg | $1,180 | In Stock |
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Purity:98.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | L-798106 (CM9) is a selective and potent prostaglandin-like EP3 receptor antagonist that inhibits EP4, EP1, and EP2 receptors, suppresses levels of pro-inflammatory cytokines in atherosclerosis, and attenuates PGE2-induced cough. |
| Targets&IC50 | EP3 receptor: 0.3 nM(ki), EP3 receptor:0.3 nM(Ki), EP1/2 receptor:> 5000 nM(ki), EP1/2 receptor:> 5000 nM(Ki), EP4 receptor:916 nM(ki), EP4 receptor:916 nM(Ki) |
| In vitro | In the guinea-pig vas deferens, L-798106 (200 nM) showed an apparent pA2 of 7.48±0.25[2]. |
| In vivo | In male db/db mice, L-798106 (50 and 100 μg/kg; oral gavage; once daily; 8 weeks) suppressed the increased fasting blood glucose levels and inhibited the increased proinflammatory gene expressions in adipocytes isolated from epididymal adipose tissue of db/db mice[3]. |
| Alias | L 798106, GW-671021, GW671021, CM-9, CM9 |
| Molecular Weight | 536.44 |
| Formula | C27H22BrNO4S |
| Cas No. | 244101-02-8 |
| Smiles | COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c1ccccc1Cc1ccc2ccccc2c1 |
| Relative Density. | 1.425 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (9.32 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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