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Laromustine
🥰Excellent
Catalog No. T70229Cas No. 173424-77-6
Alias VNP40101M, VNP 40101M
Laromustine (VNP40101M) is a sulfonyl hydrolytic alkylating prodrug used in cancer therapy with significant anticancer activity.
Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia.
Laromustine
🥰Excellent
Catalog No. T70229Alias VNP40101M, VNP 40101MCas No. 173424-77-6
Laromustine (VNP40101M) is a sulfonyl hydrolytic alkylating prodrug used in cancer therapy with significant anticancer activity.
Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia.
Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Laromustine (VNP40101M) is a sulfonyl hydrolytic alkylating prodrug used in cancer therapy with significant anticancer activity. Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia. |
| Targets&IC50 | CYP2B6:125 mM (Ki), CYP2C19:349 mM (ki), CYP3A4/5:297 mM (Ki) |
| In vitro | Laromustine caused direct inhibition of CYP2B6 and CYP3A4/5 as well as of CYP2C19. CYP2B6 K(i)=125 mM, CYP3A4/5 K(i)=297 mM, and CYP2C19 K(i)=349 mM and were greater than the average clinical plasma C(max) of Laromustine (C(max)=25 mM). [1] |
| Alias | VNP40101M, VNP 40101M |
| Molecular Weight | 307.78 |
| Formula | C6H14ClN3O5S2 |
| Cas No. | 173424-77-6 |
| Smiles | O=C(NC)N(N(CCCl)S(=O)(=O)C)S(=O)(=O)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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