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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $38 | In Stock | |
5 mg | $63 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $173 | In Stock | |
50 mg | $256 | In Stock | |
100 mg | $354 | In Stock | |
500 mg | Inquiry | In Stock |
Description | MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model. |
Targets&IC50 | MAO-B:57 nM (IC50), MAO-A:37 nM (IC50) |
In vitro | MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone and reduced the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3]. Additionally, MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4]. |
In vivo | MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) exhibits neuroprotective activities [6]. |
Alias | M 30 dihydrochloride |
Molecular Weight | 299.2 |
Formula | C14H16Cl2N2O |
Cas No. | 64821-19-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
Solubility Information | DMSO: 1.8 mg/mL (6 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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