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MAO-IN-M30 dihydrochloride

Catalog No. T38034 CAS 64821-19-8

Synonyms: M 30 dihydrochloride

MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.

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MAO-IN-M30 dihydrochloride Chemical Structure

MAO-IN-M30 dihydrochloride, CAS 64821-19-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
5 mg	In stock	$ 157.00
10 mg	In stock	$ 226.00
25 mg	In stock	$ 376.00
50 mg	In stock	$ 561.00
100 mg	In stock	$ 789.00
500 mg	In stock	$ 1,660.00

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Purity: 98.43%

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Description	MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.
Targets&IC50	MAO-A:37 nM (IC50), MAO-B:57 nM (IC50)
In vitro	MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3]. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4].
In vivo	MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6].

Synonyms	M 30 dihydrochloride
Molecular Weight	299.2
Formula	C14H16Cl2N2O
CAS No.	64821-19-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.8 mg/mL (6 mM), Sonification and heating to 60℃ are recommended.

References and Literature

1. Zheng et al (2005) Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons. Biochem.Pharmacol. 70 1642 2. Zheng (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J.Neurochem. 95 68 3. Gal et al (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal DA depletion. J.Neurochem. 95 79

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Antidepressant Compound Library Covalent Inhibitor Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max Antioxidant Compound Library Neuronal Signaling Compound Library

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Related compounds with same targets

MAO A/HSP90-IN-2 Isocarboxazid Rasagiline Isatin Desmethoxyyangonin Lysyl hydroxylase 2-IN-2 Norharmane Modaline sulfate

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Keywords

MAO-IN-M30 dihydrochloride 64821-19-8 Neuroscience Monoamine Oxidase M 30 Dihydrochloride M 30 dihydrochloride M 30 MAO-IN-M30 M-30 Dihydrochloride M30 M-30 MAO-IN-M30 Dihydrochloride M30 Dihydrochloride inhibitor inhibit

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