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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a quenched, fluorescent MMP peptide substrate designed for the real-time quantification of MMP enzymatic activity. As an extended variant of the MMP substrate (FS-1), it demonstrates increased specificity against collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP, evidenced by higher specificity constants (Ex/Em=325 nm/400 nm). [1] |
In vitro | The compound Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH26 exhibits a catalytic efficiency (kcat/Km) that is 2-9-fold higher in comparison to FS-1 for specific matrix metalloproteinases (MMP-1, MMP-8, MMP-13) and membrane-type 1-MMP (MMP-14), or a 3-fold increase according to reference [1]. |
Molecular Weight | 1221.32 |
Formula | C55H80N16O16 |
Cas No. | 720710-69-0 |
Storage | keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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