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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $118 | In Stock | |
5 mg | $291 | In Stock | |
10 mg | $432 | In Stock | |
25 mg | $715 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,360 | In Stock | |
500 mg | $2,730 | In Stock | |
1 mL x 10 mM (in DMSO) | $267 | In Stock |
Description | ME1111, a succinate dehydrogenase inhibitor of Trichophyton species, serves as an antifungal agent effective against dermatophytes. Notably proficient in penetrating human nails, it is utilized in onychomycosis research. |
In vitro | ME1111 (0.125, 0.0625 μg/mL; 4, 8, 12 h) inhibits T. mentagrophytes TIMM 2789 (MICs: 0.5 μg/mL and 0.25 μg/mL in RPMI 1640 medium and SDB, respectively).[2] ME1111 strongly inhibits the succinate-2,6-dichlorophenolindophenol reductase reaction in Trichophyton rubrum and T. mentagrophytes (IC50: 0.029 μg/mL, 0.025 μg/mL) but only shows moderate inhibition of the same reaction in human cell lines.[2] |
Molecular Weight | 202.25 |
Formula | C12H14N2O |
Cas No. | 1391758-52-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (445.0 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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